| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Edinburgh Lung and the Environment Group Initiative/Colt Laboratory, The University of Edinburgh, Department of Medicine and Radiological Sciences, Medical School, Edinburgh EH8 9AG; and 2 The School of Life Sciences, Napier University, Edinburgh EH10 5DT, United Kingdom
Increases in the levels of environmental particulate matter with a diameter of <10 µm diameter (PM10) in the air are associated with a variety of adverse health effects, particularly chronic lung and cardiovascular diseases. The expression of many inflammatory genes involves the remodeling of the chromatin structure provided by histone proteins. Histone acetylation causes the unwinding of chromatin structure, therefore allowing transcription factor access to promoter sites. Acetylation is reversible and is regulated by histone acetyltransferases (HATs), which promote acetylation, and deacetylases, which promote deacetylation. PM10 and H2O2 increased IL-8 protein release from A549 cells after 24-h treatment, and this was enhanced by histone deacetylase inhibition by trichostatin A (cotreatment). PM10 and H2O2 treatment also increased HAT activity as well as the level of acetylated histone 4 (H4). PM10 enhanced H4 acetylation that was mediated by oxidative stress as shown by thiol antioxidant inhibition. Acetylation of H4 mediated by PM10 was associated with the promoter region of the IL-8 gene. These data suggest that remodeling of chromatin by histone acetylation plays a role in PM10-mediated responses in the lungs.
interleukin-8; histone acetylation; particulate matter with diameter of <10 µm; transcription
This article has been cited by other articles:
|
|
 |
|
  I A Yang, K M Fong, P V Zimmerman, S T Holgate, and J W Holloway Genetic susceptibility to the respiratory effects of air pollution Postgrad. Med. J., August 1, 2009; 85(1006): 428 - 436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. R. Bartling and M. L. Drumm Loss of CFTR results in reduction of histone deacetylase 2 in airway epithelial cells Am J Physiol Lung Cell Mol Physiol, July 1, 2009; 297(1): L35 - L43. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. R. Bartling and M. L. Drumm Oxidative Stress Causes IL8 Promoter Hyperacetylation in Cystic Fibrosis Airway Cell Models Am. J. Respir. Cell Mol. Biol., January 1, 2009; 40(1): 58 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Chavey, M. Muhlbauer, C. Bossard, A. Freund, S. Durand, C. Jorgensen, C. Jobin, and G. Lazennec Interleukin-8 Expression Is Regulated by Histone Deacetylases through the Nuclear Factor-{kappa}B Pathway in Breast Cancer Mol. Pharmacol., November 1, 2008; 74(5): 1359 - 1366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I A Yang, K M Fong, P V Zimmerman, S T Holgate, and J W Holloway Genetic susceptibility to the respiratory effects of air pollution Thorax, June 1, 2008; 63(6): 555 - 563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Liu, M. Ballaney, U. Al-alem, C. Quan, X. Jin, F. Perera, L.-C. Chen, and R. L. Miller Combined Inhaled Diesel Exhaust Particles and Allergen Exposure Alter Methylation of T Helper Genes and IgE Production In Vivo Toxicol. Sci., March 1, 2008; 102(1): 76 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Dombrowsky and S. Uhlig Steroids and histone deacetylase in ventilation-induced gene transcription Eur. Respir. J., November 1, 2007; 30(5): 865 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Monteiller, L. Tran, W. MacNee, S. Faux, A. Jones, B. Miller, and K. Donaldson The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area Occup. Environ. Med., September 1, 2007; 64(9): 609 - 615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. W S Ko, W. Tam, T. W. Wong, D. P S Chan, A. H Tung, C. K W Lai, and D. S C Hui Temporal relationship between air pollutants and hospital admissions for chronic obstructive pulmonary disease in Hong Kong Thorax, September 1, 2007; 62(9): 780 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Celli and P. J. Barnes Exacerbations of chronic obstructive pulmonary disease Eur. Respir. J., June 1, 2007; 29(6): 1224 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Cui, J. Miao, and L. Cui Cytotoxic Effect of Curcumin on Malaria Parasite Plasmodium falciparum: Inhibition of Histone Acetylation and Generation of Reactive Oxygen Species Antimicrob. Agents Chemother., February 1, 2007; 51(2): 488 - 494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Rahman and I. M. Adcock Oxidative stress and redox regulation of lung inflammation in COPD. Eur. Respir. J., July 1, 2006; 28(1): 219 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Szulakowski, A. J. L. Crowther, L. A. Jimenez, K. Donaldson, R. Mayer, T. B. Leonard, W. MacNee, and E. M. Drost The Effect of Smoking on the Transcriptional Regulation of Lung Inflammation in Patients with Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., July 1, 2006; 174(1): 41 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Slevogt, B. Schmeck, C. Jonatat, J. Zahlten, W. Beermann, V. van Laak, B. Opitz, S. Dietel, P. D. N'Guessan, S. Hippenstiel, et al. Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-{kappa}B activation and histone deacetylase activity reduction Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L818 - L826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-M. Kim, W. Reed, W. Wu, P. A. Bromberg, L. M. Graves, and J. M. Samet Zn2+-induced IL-8 expression involves AP-1, JNK, and ERK activities in human airway epithelial cells Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L1028 - L1035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Medina-Ramon, A. Zanobetti, and J. Schwartz The Effect of Ozone and PM10 on Hospital Admissions for Pneumonia and Chronic Obstructive Pulmonary Disease: A National Multicity Study Am. J. Epidemiol., March 15, 2006; 163(6): 579 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-J. Chen, W.-C. Huang, and C.-C. Chen Transcriptional Regulation of Cyclooxygenase-2 in Response to Proteasome Inhibitors Involves Reactive Oxygen Species-mediated Signaling Pathway and Recruitment of CCAAT/Enhancer-binding Protein {delta} and CREB-binding Protein Mol. Biol. Cell, December 1, 2005; 16(12): 5579 - 5591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vineis and K. Husgafvel-Pursiainen Air pollution and cancer: biomarker studies in human populations Carcinogenesis, November 1, 2005; 26(11): 1846 - 1855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Seaton, J Cherrie, M Dennekamp, K Donaldson, J F Hurley, and C L Tran The London Underground: dust and hazards to health Occup. Environ. Med., June 1, 2005; 62(6): 355 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. MacNee Pulmonary and Systemic Oxidant/Antioxidant Imbalance in Chronic Obstructive Pulmonary Disease Proceedings of the ATS, April 1, 2005; 2(1): 50 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Arnholdt-Schmitt Stress-Induced Cell Reprogramming. A Role for Global Genome Regulation? Plant Physiology, September 1, 2004; 136(1): 2579 - 2586. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
