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1 Edinburgh Lung and the Environment Group Initiative/Colt Laboratory, The University of Edinburgh, Department of Medicine and Radiological Sciences, Medical School, Edinburgh EH8 9AG; and 2 The School of Life Sciences, Napier University, Edinburgh EH10 5DT, United Kingdom
Increases in the levels of environmental particulate matter with a diameter of <10 µm diameter (PM10) in the air are associated with a variety of adverse health effects, particularly chronic lung and cardiovascular diseases. The expression of many inflammatory genes involves the remodeling of the chromatin structure provided by histone proteins. Histone acetylation causes the unwinding of chromatin structure, therefore allowing transcription factor access to promoter sites. Acetylation is reversible and is regulated by histone acetyltransferases (HATs), which promote acetylation, and deacetylases, which promote deacetylation. PM10 and H2O2 increased IL-8 protein release from A549 cells after 24-h treatment, and this was enhanced by histone deacetylase inhibition by trichostatin A (cotreatment). PM10 and H2O2 treatment also increased HAT activity as well as the level of acetylated histone 4 (H4). PM10 enhanced H4 acetylation that was mediated by oxidative stress as shown by thiol antioxidant inhibition. Acetylation of H4 mediated by PM10 was associated with the promoter region of the IL-8 gene. These data suggest that remodeling of chromatin by histone acetylation plays a role in PM10-mediated responses in the lungs.
interleukin-8; histone acetylation; particulate matter with diameter of <10 µm; transcription
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