AJP - Lung Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 285: L240-L249, 2003. First published March 7, 2003; doi:10.1152/ajplung.00319.2002
1040-0605/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/1/L240    most recent
00319.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (31)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shimoda, K.
Right arrow Articles by Traber, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shimoda, K.
Right arrow Articles by Traber, D. L.

Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep

Katsumi Shimoda,1 Kazunori Murakami,1 Perenlei Enkhbaatar,1 Lillian D. Traber,1 Robert A. Cox,1 Hal K. Hawkins,1 Frank C. Schmalstieg,1 Katalin Komjáti,2 Jon G. Mabley,2 Csaba Szabó,2 Andrew L. Salzman,2 and Daniel L. Traber1

1Departments of Anesthesiology, Pathology, and Pediatrics, The University of Texas Medical Branch, Shriners Burns Hospital, Galveston, Texas 77555-0833; and 2Inotek Pharmaceuticals, Beverly, Massachusetts 01915

Submitted 20 September 2002 ; accepted in final form 28 February 2003

We investigated the role of the nuclear enzyme poly (ADP ribose) synthetase (PARS) in the pathogenesis of combined burn and smoke inhalation (burn/smoke) injury in an ovine model. Eighteen sheep were operatively prepared for chronic study. PARS inhibition was achieved by treatment with a novel and selective PARS inhibitor INO-1001. The PARS inhibitor attenuated 1) lung edema formation, 2) deterioration of gas exchange, 3) changes in airway blood flow, 4) changes in airway pressure, 5) lung histological injury, and 6) systemic vascular leakage. Lipid oxidation and plasma nitrite/nitrate (stable breakdown products of nitric oxide) levels were suppressed with the use of INO-1001. We conclude that PARS inhibition attenuates various aspects of the pathophysiological response in a clinically relevant experimental model of burn/smoke inhalation injury.

acute respiratory distress syndrome; lung lymphatic; nitric oxide


Address for reprint requests and other correspondence: D. L. Traber, Investigational Intensive Care Unit, Dept. of Anesthesiology, The Univ. of Texas Medical Branch, 610 Texas Ave., Galveston, TX 77555-0833 (E-mail: dltraber{at}utmb.edu).




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
O. L. Syrkina, D. A. Quinn, W. Jung, B. Ouyang, and C. A. Hales
Inhibition of JNK activation prolongs survival after smoke inhalation from fires
Am J Physiol Lung Cell Mol Physiol, April 1, 2007; 292(4): L984 - L991.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
C. L. Cheng, S. P. Johnson, S. T. Keir, J. A. Quinn, F. Ali-Osman, C. Szabo, H. Li, A. L. Salzman, M. E. Dolan, P. Modrich, et al.
Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft
Mol. Cancer Ther., September 1, 2005; 4(9): 1364 - 1368.
[Abstract] [Full Text] [PDF]

Home page
 TraumaHome page
L. C Cancio
Current concepts in the pathophysiology and treatment of inhalation injury
Trauma, January 1, 2005; 7(1): 19 - 35.
[Abstract] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
P. Pacher, A. Vaslin, R. Benko, J. G. Mabley, L. Liaudet, G. Hasko, A. Marton, S. Batkai, M. Kollai, and C. Szabo
A New, Potent Poly(ADP-ribose) Polymerase Inhibitor Improves Cardiac and Vascular Dysfunction Associated with Advanced Aging
J. Pharmacol. Exp. Ther., November 1, 2004; 311(2): 485 - 491.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.