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Am J Physiol Lung Cell Mol Physiol 285: L773-L781, 2003; doi:10.1152/ajplung.00023.2003
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INVITED REVIEW

C/EBP transcription factors in the lung epithelium

Tobias N. Cassel1 and Magnus Nord2

1Institute for Cancer Studies, Division of Genomic Medicine, University of Sheffield, Sheffield S10 2RX, United Kingdom; and 2Department of Medical Nutrition, Novum, Karolinska Institutet, SE 141 86 Huddinge, Sweden

During recent years, the biological roles of CCAAT/enhancer binding proteins (C/EBPs) in the lung have started to be uncovered. C/EBPs form a family within the basic region-leucine zipper class of transcription factors. In the lung epithelium C/EBP{alpha}, -{beta}, and -{delta} are expressed. Lung-specific target genes for these transcription factors include the surfactant proteins A and D, the Clara cell secretory protein, and the P450 enzyme CYP2B1. As more information is gathered, a picture is emerging in which C/EBP{alpha} has a role in regulating proliferation as well as differentiation-dependent gene expression, whereas C/EBP{beta} and -{delta}, in addition to a partly overlapping role in regulating expression of differentiation markers, also seem to be involved in responses to injury and hormones.

CCAAT/enhancer binding protein; differentiation; gene expression regulation; proliferation regulation


Address for reprint requests and other correspondence: M. Nord, Dept. of Medical Nutrition, Karolinska Institutet, Novum, Huddinge Univ. Hospital, SE 141 86 Huddinge, Sweden (E-mail: magnus.nord{at}mednut.ki.se).




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