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EB2004 FEATURED TOPIC REPORT

Cell-cell interactions in regulating lung function

¹Department of Physiology, University of Arizona Health Sciences Center, Tucson, Arizona 85724; ²Lung Biology Laboratory and ³Division of Pulmonary-Critical Care Medicine, St. Luke’s-Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, New York 10019; ⁴Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 4N1; and ⁵Department of Physiology and Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104

Tight junction barrier formation and gap junctional communication are two functions directly attributable to cell-cell contact sites. Epithelial and endothelial tight junctions are critical elements of the permeability barrier required to maintain discrete compartments in the lung. On the other hand, gap junctions enable a tissue to act as a cohesive unit by permitting metabolic coupling and enabling the direct transmission of small cytosolic signaling molecules from one cell to another. These components do not act in isolation since other junctional elements, such as adherens junctions, help regulate barrier function and gap junctional communication. Some fundamental elements related to regulation of pulmonary barrier function and gap junctional communication were presented in a Featured Topic session at the 2004 Experimental Biology Conference in Washington, DC, and are reviewed in this summary.

tight junction; gap junction; claudin; connexin; cadherin; calcium

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