| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1Division of Pulmonary & Critical Care Medicine and 3Department of Medicine, University of Washington, Seattle 98195; and 2Medical Research Service, Veterans Affairs Puget Sound Healthcare System, Seattle, Washington 98108
Submitted 9 January 2004 ; accepted in final form 8 May 2004
Previous animal studies have identified a role for activation of innate immunity in the pathogenesis of ventilator-associated lung injury. These studies have used large tidal volume ventilation to study the effect of alveolar overdistension on induction of inflammatory pathways. We hypothesized an alternative mechanism for the pathogenesis of lung injury in which moderate tidal volume ventilation does not independently cause clinical inflammation but rather interacts with innate immune activation by bacterial products, resulting in an enhanced inflammatory response. We measured cytokine expression and lung injury in normal and lipopolysaccharide (LPS)-treated anesthetized rabbits randomized to either spontaneous respiration or mechanical ventilation. Outcome parameters were analyzed by two-way factorial analysis of variance to identify synergism between ventilation and systemic LPS. Mechanical ventilation alone resulted in minimal cytokine expression in the lung but did enhance LPS-induced expression of tumor necrosis factor-
, the CXC chemokines interleukin-8 and growth-related protein-, and the CC chemokine monocyte chemoattractant protein-1. Increased mRNA expression and activation of the transcription factors nuclear factor-
B and activator protein-1 accompanied the cytokine responses. We conclude that moderate volume ventilation strategies augment the innate immune response to bacterial products in the lung and may play a role in the development of acute lung injury in patients with sepsis.
acute lung injury; innate immunity; transcription factor-1; nuclear factor-B
This article has been cited by other articles:
|
|
 |
|
  G. R. Zosky, V. Cannizzaro, Z. Hantos, and P. D. Sly Protective mechanical ventilation does not exacerbate lung function impairment or lung inflammation following influenza A infection J Appl Physiol, November 1, 2009; 107(5): 1472 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Wilson, K. P. O'Dea, D. Zhang, A. D. Shearman, N. van Rooijen, and M. Takata Role of Lung-marginated Monocytes in an In Vivo Mouse Model of Ventilator-induced Lung Injury Am. J. Respir. Crit. Care Med., May 15, 2009; 179(10): 914 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Gharib, W. C. Liles, L. S. Klaff, and W. A. Altemeier Noninjurious mechanical ventilation activates a proinflammatory transcriptional program in the lung Physiol Genomics, May 13, 2009; 37(3): 239 - 248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Bem, J. B. M. van Woensel, A. P. Bos, A. Koski, A. W. Farnand, J. B. Domachowske, H. F. Rosenberg, T. R. Martin, and G. Matute-Bello Mechanical ventilation enhances lung inflammation and caspase activity in a model of mouse pneumovirus infection Am J Physiol Lung Cell Mol Physiol, January 1, 2009; 296(1): L46 - L56. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Kuiper, A. M. G. Versteilen, H. W. M. Niessen, R. R. Vaschetto, P. Sipkema, C. J. Heijnen, A. B. J. Groeneveld, and F. B. Plotz Production of Endothelin-1 and Reduced Blood Flow in the Rat Kidney During Lung-Injurious Mechanical Ventilation Anesth. Analg., October 1, 2008; 107(4): 1276 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Matute-Bello, C. W. Frevert, and T. R. Martin Animal models of acute lung injury Am J Physiol Lung Cell Mol Physiol, September 1, 2008; 295(3): L379 - L399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Otto, K. Markstaller, O. Kajikawa, J. Karmrodt, R. S. Syring, B. Pfeiffer, V. P. Good, C. W. Frevert, and J. E. Baumgardner Spatial and temporal heterogeneity of ventilator-associated lung injury after surfactant depletion J Appl Physiol, May 1, 2008; 104(5): 1485 - 1494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. R. Martin Interactions between Mechanical and Biological Processes in Acute Lung Injury Proceedings of the ATS, April 15, 2008; 5(3): 291 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J A Frank, J-F Pittet, C Wray, and M A Matthay Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade Thorax, February 1, 2008; 63(2): 147 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Papaiahgari, A. Yerrapureddy, S. R. Reddy, N. M. Reddy, J. M. Dodd-O, M. T. Crow, D. N. Grigoryev, K. Barnes, R. M. Tuder, M. Yamamoto, et al. Genetic and Pharmacologic Evidence Links Oxidative Stress to Ventilator-induced Lung Injury in Mice Am. J. Respir. Crit. Care Med., December 15, 2007; 176(12): 1222 - 1235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. H. Hillman, T. J. M. Moss, S. G. Kallapur, C. Bachurski, J. J. Pillow, G. R. Polglase, I. Nitsos, B. W. Kramer, and A. H. Jobe Brief, Large Tidal Volume Ventilation Initiates Lung Injury and a Systemic Response in Fetal Sheep Am. J. Respir. Crit. Care Med., September 15, 2007; 176(6): 575 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J Schultz and M. Levi Pulmonary coagulopathy: a potential therapeutic target in different forms of lung injury Thorax, July 1, 2007; 62(7): 563 - 564. [Full Text] [PDF]
|
|
|
|
|
|
S. Ota, K. Nakamura, T. Yazawa, Y. Kawaguchi, Y. Baba, R. Kitaoka, N. Morimura, T. Goto, Y. Yamada, and K. Kurahashi High tidal volume ventilation induces lung injury after hepatic ischemia-reperfusion Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L625 - L631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Wurfel Microarray-based Analysis of Ventilator-induced Lung Injury Proceedings of the ATS, January 1, 2007; 4(1): 77 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Okutani, B. Han, M. Mura, T. K. Waddell, S. Keshavjee, and M. Liu High-volume ventilation induces pentraxin 3 expression in multiple acute lung injury models in rats Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L144 - L153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Frank, P. E. Parsons, and M. A. Matthay Pathogenetic Significance of Biological Markers of Ventilator-Associated Lung Injury in Experimental and Clinical Studies Chest, December 1, 2006; 130(6): 1906 - 1914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Gharib, W. C. Liles, G. Matute-Bello, R. W. Glenny, T. R. Martin, and W. A. Altemeier Computational Identification of Key Biological Modules and Transcription Factors in Acute Lung Injury Am. J. Respir. Crit. Care Med., March 15, 2006; 173(6): 653 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Martin and C. W. Frevert Innate Immunity in the Lungs Proceedings of the ATS, December 1, 2005; 2(5): 403 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tsuchida, D. Engelberts, M. Roth, C. McKerlie, M. Post, and B. P. Kavanagh Continuous positive airway pressure causes lung injury in a model of sepsis Am J Physiol Lung Cell Mol Physiol, October 1, 2005; 289(4): L554 - L564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Wilson, S. Choudhury, and M. Takata Pulmonary inflammation induced by high-stretch ventilation is mediated by tumor necrosis factor signaling in mice Am J Physiol Lung Cell Mol Physiol, April 1, 2005; 288(4): L599 - L607. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
