AJP - Lung Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol 287: L895-L901, 2004; doi:10.1152/ajplung.00075.2004
1040-0605/04 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (20)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Predescu, D.
Right arrow Articles by Malik, A. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Predescu, D.
Right arrow Articles by Malik, A. B.

INVITED REVIEW

Functional and morphological studies of protein transcytosis in continuous endothelia

Dan Predescu, Stephen M. Vogel, and Asrar B. Malik

Department of Pharmacology, The University of Illinois College of Medicine, Chicago, Illinois 60612

Continuous microvascular endothelium constitutively transfers protein from vessel lumen to interstitial space. Compelling recent biochemical, ultrastructural, and physiological evidence reviewed herein demonstrates that protein transport is not the result of barrier "leakiness" but, rather, is an active process occurring primarily in a transendothelial vesicular pathway. Protein accesses the vesicular pathway by means of caveolae open to the vessel lumen. Vascular tracer proteins appear in free cytoplasmic vesicles within minutes; contents of transport vesicles are rapidly deposited into the subendothelial matrix by exocytosis. Caveolin-1 deficiency eliminates caveolae and abolishes vesicular protein transport; interestingly, exchange vessels develop a compensatory transport mode through the opening of a paracellular permeability pathway. The evidence supports the transcytosis hypothesis and the concept that transcytosis is a fundamental component of transendothelial permeability of macromolecules.

albumin; caveolae; filipin; microvascular endothelium


Address for reprint requests and other correspondence: S. M. Vogel, Univ. of Illinois at Chicago, College of Medicine, Dept. of Pharmacology, 835 S. Wolcott Ave., (M/C 868), Chicago, Illinois 60612 (E-mail: vogel{at}uic.edu)




This article has been cited by other articles:


Home page
 FASEB J.Home page
M. P. W. Moos, J. D. Mewburn, F. W. K. Kan, S. Ishii, M. Abe, K. Sakimura, K. Noguchi, T. Shimizu, and C. D. Funk
Cysteinyl leukotriene 2 receptor-mediated vascular permeability via transendothelial vesicle transport
FASEB J, December 1, 2008; 22(12): 4352 - 4362.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. A. Predescu, D. N. Predescu, and A. B. Malik
Molecular determinants of endothelial transcytosis and their role in endothelial permeability
Am J Physiol Lung Cell Mol Physiol, October 1, 2007; 293(4): L823 - L842.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. S. Siddiqui, Z. K. Siddiqui, S. Uddin, R. D. Minshall, and A. B. Malik
p38 MAPK activation coupled to endocytosis is a determinant of endothelial monolayer integrity
Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L114 - L124.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. Cavelier, L. Rohrer, and A. von Eckardstein
ATP-Binding Cassette Transporter A1 Modulates Apolipoprotein A-I Transcytosis Through Aortic Endothelial Cells
Circ. Res., November 10, 2006; 99(10): 1060 - 1066.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
L.-M. Zhang, C. St. Croix, R. Cao, K. Wasserloos, S. C. Watkins, T. Stevens, S. Li, V. Tyurin, V. E. Kagan, and B. R. Pitt
Cell-surface protein disulfide isomerase is required for transnitrosation of metallothionein by s-nitroso-albumin in intact rat pulmonary vascular endothelial cells.
Experimental Biology and Medicine, October 1, 2006; 231(9): 1507 - 1515.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
B.-S. Ding, T. Dziubla, V. V. Shuvaev, S. Muro, and V. R. Muzykantov
Advanced drug delivery systems that target the vascular endothelium.
Mol. Interv., April 1, 2006; 6(2): 98 - 112.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. C. Mora, V. L. Bonilha, B.-C. Shin, J. Hu, L. Cohen-Gould, D. Bok, and E. Rodriguez-Boulan
Bipolar assembly of caveolae in retinal pigment epithelium
Am J Physiol Cell Physiol, March 1, 2006; 290(3): C832 - C843.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
D. Mehta and A. B. Malik
Signaling Mechanisms Regulating Endothelial Permeability
Physiol Rev, January 1, 2006; 86(1): 279 - 367.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
A. Tagawa, A. Mezzacasa, A. Hayer, A. Longatti, L. Pelkmans, and A. Helenius
Assembly and trafficking of caveolar domains in the cell: caveolae as stable, cargo-triggered, vesicular transporters
J. Cell Biol., August 29, 2005; 170(5): 769 - 779.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the American Physiological Society.