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This Article Full Text Full Text (PDF) All Versions of this Article: 287/6/L1107    most recent 00119.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (14) Citing Articles via Google Scholar Google Scholar Articles by Foster, D. J. Articles by Hsia, C. C. W. Search for Related Content PubMed PubMed Citation Articles by Foster, D. J. Articles by Hsia, C. C. W.

Upregulation of erythropoietin receptor during postnatal and postpneumonectomy lung growth

¹Department of Internal Medicine, University of Texas Southwestern Medical Center and ²Medical Service, Department of Veterans Affairs Medical Center, Dallas, Texas 75390-9034

Submitted 29 March 2004 ; accepted in final form 27 July 2004

Circulating erythropoietin (EPO) stimulates erythrocytosis, whereas organ-specific local EPO receptor (EPOR) expression has been linked to angiogenesis, tissue growth, and development. On the basis of the observation of concurrent enhancement of lung growth and erythrocyte production during exposure to chronic hypoxia, we hypothesized that a paracrine EPO system is involved in mediating lung growth. We analyzed EPOR protein expression in normal dog lung tissue during postnatal maturation and during compensatory lung growth after right pneumonectomy (PNX). Membrane-bound EPOR was significantly more abundant in the immature lung compared with mature lung and in the remaining lung 3 wk after PNX compared with matched sham controls. COOH-terminal cytosolic EPOR peptides, which were even more abundant than membrane-bound EPOR, were also upregulated in immature lung but differentially processed after PNX. Apoptosis was enhanced during both types of lung growth in direct relationship to cellular proliferation and EPOR expression. We conclude that both developmental and compensatory lung growth involve paracrine EPO signaling with parallel upregulation but differential processing of EPOR.

dog; postnatal development and maturation; compensatory lung growth; apoptosis; immunohistochemistry; immunoblot

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