| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
INVITED REVIEW
1Department of Pharmacology, National University of Singapore; and 2Centre for Biomedical Sciences, Defence Medical and Environmental Research Institute, Singapore
A characteristic feature of all inflammatory disorders is the excessive recruitment of leukocytes to the site of inflammation. The loss of control in trafficking these cells contributes to inflammatory diseases. Leukocyte recruitment is a well-orchestrated process that includes several protein families including the large cytokine subfamily of chemotactic cytokines, the chemokines. Chemokines and their receptors are involved in the pathogenesis of several diseases. Acute lung injury that clinically manifests as acute respiratory distress syndrome (ARDS) is caused by an uncontrolled systemic inflammatory response resulting from clinical events including major surgery, trauma, multiple transfusions, severe burns, pancreatitis, and sepsis. Systemic inflammatory response syndrome involves activation of alveolar macrophages and sequestered neutrophils in the lung. The clinical hallmarks of ARDS are severe hypoxemia, diffuse bilateral pulmonary infiltrates, and normal intracardiac filling pressures. The magnitude and duration of the inflammatory process may ultimately determine the outcome in patients with ARDS. Recent evidence shows that activated leukocytes and chemokines play a key role in the pathogenesis of ARDS. The expanding number of antagonists of chemokine receptors for inflammatory disorders may hold promise for new medicines to combat ARDS.
inflammatory mediators; polymorphonuclear leukocyte; pathogenesis; antagonists
This article has been cited by other articles:
|
|
 |
|
  S. Apostolakis, K. Vogiatzi, V. Amanatidou, and D. A. Spandidos Interleukin 8 and cardiovascular disease Cardiovasc Res, August 4, 2009; (2009) cvp241v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Bajwa, U. A. Khan, J. L. Januzzi, M. N. Gong, B. T. Thompson, and D. C. Christiani Plasma C-Reactive Protein Levels Are Associated With Improved Outcome in ARDS Chest, August 1, 2009; 136(2): 471 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Rockx, T. Baas, G. A. Zornetzer, B. Haagmans, T. Sheahan, M. Frieman, M. D. Dyer, T. H. Teal, S. Proll, J. van den Brand, et al. Early Upregulation of Acute Respiratory Distress Syndrome-Associated Cytokines Promotes Lethal Disease in an Aged-Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Infection J. Virol., July 15, 2009; 83(14): 7062 - 7074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I Risnes, K Wagner, T Ueland, T. Mollnes, P Aukrust, and J. Svennevig Interleukin-6 may predict survival in extracorporeal membrane oxygenation treatment Perfusion, May 1, 2008; 23(3): 173 - 178. [Abstract] [PDF]
|
|
|
|
 |
|
 W. von Wulffen, M. Steinmueller, S. Herold, L. M. Marsh, P. Bulau, W. Seeger, T. Welte, J. Lohmeyer, and U. A. Maus Lung Dendritic Cells Elicited by Fms-like Tyrosin 3-Kinase Ligand Amplify the Lung Inflammatory Response to Lipopolysaccharide Am. J. Respir. Crit. Care Med., November 1, 2007; 176(9): 892 - 901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. H. Hillman, T. J. M. Moss, S. G. Kallapur, C. Bachurski, J. J. Pillow, G. R. Polglase, I. Nitsos, B. W. Kramer, and A. H. Jobe Brief, Large Tidal Volume Ventilation Initiates Lung Injury and a Systemic Response in Fetal Sheep Am. J. Respir. Crit. Care Med., September 15, 2007; 176(6): 575 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. P Singh, L. Bhagat, S. Navina, R. Sharif, R. K Dawra, and A. K Saluja Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion Gut, July 1, 2007; 56(7): 958 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. He, R. Horuk, S. M. Moochhala, and M. Bhatia Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis Am J Physiol Gastrointest Liver Physiol, April 1, 2007; 292(4): G1173 - G1180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Jacono, Y.-J. Peng, D. Nethery, J. A. Faress, Z. Lee, J. A. Kern, and N. R. Prabhakar Acute lung injury augments hypoxic ventilatory response in the absence of systemic hypoxemia J Appl Physiol, December 1, 2006; 101(6): 1795 - 1802. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S V Baudouin Manipulation of inflammation in ARDS: achievable goal or distant target? Thorax, June 1, 2006; 61(6): 464 - 465. [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Liu and A. B. Malik NF-{kappa}B activation as a pathological mechanism of septic shock and inflammation Am J Physiol Lung Cell Mol Physiol, April 1, 2006; 290(4): L622 - L645. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pirat, P. Zeyneloglu, D. Aldemir, M. Yucel, O. Ozen, S. Candan, and G. Arslan Pretreatment with Simvastatin Reduces Lung Injury Related to Intestinal Ischemia-Reperfusion in Rats Anesth. Analg., January 1, 2006; 102(1): 225 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. L.-S. Tang, P. K.-S. Chan, C.-K. Wong, K.-F. To, A. K.-L. Wu, Y.-M. Sung, D. S.-C. Hui, J. J.-Y. Sung, and C. W.-K. Lam Early Enhanced Expression of Interferon-Inducible Protein-10 (CXCL-10) and Other Chemokines Predicts Adverse Outcome in Severe Acute Respiratory Syndrome Clin. Chem., December 1, 2005; 51(12): 2333 - 2340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Reutershan, A. Basit, E. V. Galkina, and K. Ley Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury Am J Physiol Lung Cell Mol Physiol, November 1, 2005; 289(5): L807 - L815. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
