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Am J Physiol Lung Cell Mol Physiol 290: L209-L221, 2006; doi:10.1152/ajplung.00185.2005
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INVITED REVIEW

Vascular endothelial growth factor in the lung

Norbert F. Voelkel,1 R. William Vandivier,1 and Rubin M. Tuder2

1University of Colorado Health Sciences Center, Pulmonary and Critical Care Division, Denver, Colorado; and 2Divisions of Cardiopulmonary Pathology and Pulmonary and Critical Care Medicine, Departments of Pathology and Medicine, Johns Hopkins University, Baltimore, Maryland

Vascular endothelial growth factor (VEGF) is a pluripotent growth and permeability factor that has a broad impact on endothelial cell function. The lung tissue is very rich in this protein; many different lung cells produce VEGF and also respond to VEGF. VEGF is critical for the development of the lung and serves as a maintenance factor during adult life. In addition to the physiological functions of this protein, there is increasing evidence that VEGF also plays a role in several acute and chronic lung diseases, such as acute lung injury, severe pulmonary hypertension, and emphysema. Here we provide a comprehensive overview of the rapidly expanding literature.


Address for reprint requests and other correspondence: N. F. Voelkel, Division of Pulmonary Sciences and Critical Care Medicine, 4200 E. Ninth Ave., C272, Denver, CO 80262 (e-mail: norbert.voelkel{at}uchsc.edu)




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