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INVITED REVIEW
1University of Colorado Health Sciences Center, Pulmonary and Critical Care Division, Denver, Colorado; and 2Divisions of Cardiopulmonary Pathology and Pulmonary and Critical Care Medicine, Departments of Pathology and Medicine, Johns Hopkins University, Baltimore, Maryland
Vascular endothelial growth factor (VEGF) is a pluripotent growth and permeability factor that has a broad impact on endothelial cell function. The lung tissue is very rich in this protein; many different lung cells produce VEGF and also respond to VEGF. VEGF is critical for the development of the lung and serves as a maintenance factor during adult life. In addition to the physiological functions of this protein, there is increasing evidence that VEGF also plays a role in several acute and chronic lung diseases, such as acute lung injury, severe pulmonary hypertension, and emphysema. Here we provide a comprehensive overview of the rapidly expanding literature.
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