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EB2006 SYMPOSIUM REPORT

Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury

¹Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee; ²Cardiovascular Research Institute, University of California, San Francisco, California; ³Pulmonary and Critical Care Medicine, Duke University, Durham, North Carolina; ⁴Department of Intensive Care and Laboratory for Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; and ⁵Departments of Medicine and Anesthesia, University of California, San Francisco, California

ABSTRACT

Substantial progress has been made in understanding the contribution of alterations in coagulation and fibrinolysis to the pathogenesis of acute lung injury (ALI). Findings from mouse, rat, baboon, and human studies indicate that alterations in coagulation and fibrinolysis may be of major pathogenetic importance in ALI and other inflammatory conditions in the lung including pneumonia, sepsis, and ventilator-induced lung injury. Therapies targeted at both activation of coagulation through the extrinsic coagulation cascade and modulation of coagulation through the protein C system have the potential to favorably impact clinical ALI/acute respiratory distress syndrome.

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