AJP - Lung Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


Am J Physiol Lung Cell Mol Physiol 294: L601-L611, 2008. First published January 4, 2008; doi:10.1152/ajplung.00320.2007
1040-0605/08 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
294/4/L601    most recent
00320.2007v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Henson, P. M.
Right arrow Articles by Tuder, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Henson, P. M.
Right arrow Articles by Tuder, R. M.

INVITED REVIEW

Apoptosis in the lung: induction, clearance and detection

P. M. Henson and R. M. Tuder

Department of Pediatrics, National Jewish Medical and Research Center, and Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Pathology, University of Colorado at Denver and Health Sciences Center, Denver, Colorado

Apoptosis and other forms of programmed cell death are important contributors to lung pathophysiology. In this brief review, we discuss some of the implications of finding apoptotic cells in the lung and methods for their detection. The balance between induction of apoptosis and the normally highly efficient clearance of such cells shows that these are highly dynamic processes and suggests that abnormalities of apoptotic cell clearance may be an alternative explanation for their detection. Because recognition of apoptotic cells by other lung cells has additional effects on inflammation, immunity, and tissue repair, local responses to the dying cells may also have important consequences in addition to the cell death itself.

efferocytosis; inflammation



Address for reprint requests and other correspondence: P. M. Henson, Dept. of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St., Denver, CO 80206 (e-mail: hensonp{at}njc.org)




This article has been cited by other articles:


Home page
Am. J. Respir. Cell Mol. Bio.Home page
N. A. Maniatis, V. Harokopos, A. Thanassopoulou, N. Oikonomou, V. Mersinias, W. Witke, S. E. Orfanos, A. Armaganidis, C. Roussos, A. Kotanidou, et al.
A Critical Role for Gelsolin in Ventilator-Induced Lung Injury
Am. J. Respir. Cell Mol. Biol., October 1, 2009; 41(4): 426 - 432.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
C. D. Sadik, M. Bachmann, J. Pfeilschifter, and H. Muhl
Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA
Nucleic Acids Res., August 1, 2009; 37(15): 5041 - 5056.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
F. Blasi and N. Sidenius
Efferocytosis: another function of uPAR
Blood, July 23, 2009; 114(4): 752 - 753.
[Full Text] [PDF]


Home page
BloodHome page
Y.-J. Park, G. Liu, Y. Tsuruta, E. Lorne, and E. Abraham
Participation of the urokinase receptor in neutrophil efferocytosis
Blood, July 23, 2009; 114(4): 860 - 870.
[Abstract] [Full Text] [PDF]


Home page
ThoraxHome page
N Oikonomou, A Thanasopoulou, A Tzouvelekis, V Harokopos, T Paparountas, I Nikitopoulou, W Witke, A Karameris, A Kotanidou, D Bouros, et al.
Gelsolin expression is necessary for the development of modelled pulmonary inflammation and fibrosis
Thorax, June 1, 2009; 64(6): 467 - 475.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
D. Sanmun, E. Witasp, S. Jitkaew, Y. Y. Tyurina, V. E. Kagan, A. Ahlin, J. Palmblad, and B. Fadeel
Involvement of a functional NADPH oxidase in neutrophils and macrophages during programmed cell clearance: implications for chronic granulomatous disease
Am J Physiol Cell Physiol, January 1, 2009; 297(3): C621 - C631.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Cell Mol. Bio.Home page
C. G. Lee, D. Hartl, H. Matsuura, F. M. Dunlop, P. D. Scotney, L. J. Fabri, A. D. Nash, N.-Y. Chen, C.-Y. Tang, Q. Chen, et al.
Endogenous IL-11 Signaling Is Essential in Th2- and IL-13-Induced Inflammation and Mucus Production
Am. J. Respir. Cell Mol. Biol., December 1, 2008; 39(6): 739 - 746.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2008 by the American Physiological Society.