HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: 294/6/L1035    most recent 00397.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Google Scholar Articles by Summer, R. Articles by Walsh, K. PubMed PubMed Citation Articles by Summer, R. Articles by Walsh, K.

EDITORIAL FOCUS

Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice

¹The Pulmonary Center, Boston University School of Medicine, ²Whitaker Cardiovascular Institute, Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine, and ³Department of Biomedical Engineering, Boston University, Boston, Massachusetts

Submitted 24 September 2007 ; accepted in final form 7 March 2008

Adiponectin is an adipocyte-derived collectin that acts on a wide range of tissues including liver, brain, heart, and vascular endothelium. To date, little is known about the actions of adiponectin in the lung. Herein, we demonstrate that adiponectin is present in lung lining fluid and that adiponectin deficiency leads to increases in proinflammatory mediators and an emphysema-like phenotype in the mouse lung. Alveolar macrophages from adiponectin-deficient mice spontaneously display increased production of tumor necrosis factor- (TNF-) and matrix metalloproteinase (MMP-12) activity. Consistent with these observations, we found that pretreatment of alveolar macrophages with adiponectin leads to TNF- and MMP-12 suppression. Together, our findings show that adiponectin leads to macrophage suppression in the lung and suggest that adiponectin-deficient states may contribute to the pathogenesis of inflammatory lung conditions such as emphysema.

lung; matrix metalloproteinases; collectin

This article has been cited by other articles:

				S. E. Wert Does adiponectin play a role in pulmonary emphysema? Am J Physiol Lung Cell Mol Physiol, June 1, 2008; 294(6): L1032 - L1034. [Full Text] [PDF]