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Fig. 5. Blockade of HMGB1 decreases hemorrhage-induced lung leak and neutrophil accumulation. One hour after the induction of hemorrhage, mice were injected with either control chicken IgY [Hem+Cont antibodies (Ab), 200 µg/mice] or polyclonal chicken IgY anti-HMGB1 antibodies (Hem+Anti-HMGB1, 200 µg/mice). Lung leak (A) and MPO (B) were then measured in control, unmanipulated animals, mice were injected with polyclonal chicken IgY anti-HMGB1 without hemorrhage (Anti-HMGB1), hemorrhaged mice were injected with control chicken IgY antibodies (Hem+Cont Ab), or hemorrhaged mice were treated with anti-HMGB1 antibodies (Hem+Anti-HMGB1) at the time points when maximal alterations were present after hemorrhage (i.e., 24 h after hemorrhage for lung leak and 4 h after blood loss for MPO, as shown in Fig. 3). Each experimental group consisted of 5 mice. The data shown are representative of 3 independent experiments. Values are presented as means ± SE. *P < 0.05 vs. control and anti-HMGB1; P < 0.05 vs. Hem+Cont Ab.

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