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LETTER TO THE EDITOR

Reply to Huang

University of Western Ontario, London, Ontario, Canada

REPLY: We would first like to thank Dr. Huang for his interest in our recent publication (4) and appreciate the opportunity to respond to his comments (1).

Although in the final version of our paper we have only included our results of dynamic lung compliance, both dynamic compliance and static compliance using pressure-volumes curves were measured in this study. Both measurements of compliance showed identical trends, displaying that TIMP-3 null mice had a rapid increase in lung compliance in response to a septic insult that was prevented in the absence of alveolar macrophages. Since including both of these results seemed repetitive, only dynamic compliance was included in the published version. This decision was made based on the facts that 1) traditional pressure-volume curves of TIMP-3 null mice exposed to sepsis (cecal ligation and perforation-induced sepsis and LPS) had been previously published in the two preceding studies (2, 3) and therefore is well established and 2) dynamic compliance is more clinically and physiologically relevant since it assesses lung elastic and recoil properties during normal tidal breathing. Since the use of both the flexiVent and the measurement of dynamic compliance to assess the lung recoil properties are well established, we believe that even in the absence of static compliance data, our results remain convincing and their conclusions well-founded.

FOOTNOTES

Address for reprint requests and other correspondence: R. A. W. Veldhuizen, Lawson Health Research Institute F4-117, 268 Grosvenor St., London, ON, Canada N6A 4V2 (e-mail: rveldhui{at}uwo.ca)

REFERENCES

1. Huang Y-C. Lung compliance measurement in mice. Am J Physiol Lung Cell Mol Physiol. doi:10.1152/ajplung.00052.2008.[Free Full Text]
2. Martin EL, McCaig LA, Moyer BZ, Pape MC, Leco KJ, Lewis JF, Veldhuizen RA. Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia. Am J Physiol Lung Cell Mol Physiol 289: L244–L251, 2005.[Abstract/Free Full Text]
3. Martin EL, Moyer BZ, Pape MC, Starcher B, Leco KJ, Veldhuizen RA. Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis. Am J Physiol Lung Cell Mol Physiol 285: L1222–L1232, 2003.[Abstract/Free Full Text]
4. Martin EL, Sheikh TA, Leco KJ, Lewis JF, Veldhuizen RA. Contribution of alveolar macrophages to the response of the TIMP-3 null lung during a septic insult. Am J Physiol Lung Cell Mol Physiol 293: L779–L789, 2007.[Abstract/Free Full Text]

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Martin, E. L. Articles by Veldhuizen, R. A. W. Search for Related Content PubMed Articles by Martin, E. L. Articles by Veldhuizen, R. A. W.