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Am J Physiol Lung Cell Mol Physiol (March 31, 2006). doi:10.1152/ajplung.00005.2006
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Submitted on January 3, 2006
Accepted on March 28, 2006

THE HIGH AFFINITY IGE RECEPTOR (FC{epsilon}RI): A CRITICAL REGULATOR OF AIRWAY SMOOTH MUSCLE CELLS ?"

Abdelilah Soussi Gounni1*

1 Immunology, University of Manitoba, Winnipeg, Canada

* To whom correspondence should be addressed. E-mail: gounni{at}cc.manitoba.ca.

The airway smooth muscle (ASM) has been typically described as a contractile tissue, responding to neurotransmitters and inflammatory mediators. However, it has been recently recognized that ASM cells can also secrete cytokines and chemokines and express cell adhesion molecules that are important for the perpetuation and modulation of airway inflammation. Recent progress has revealed the importance of IgE Fc receptors in stimulating and modulating the function of these cells. In particular, the high affinity receptor for IgE (Fce{epsilon}RI) has been identified in primary human ASM cells in vitro and in vivo within bronchial biopsies of atopic asthmatic individuals. Moreover, activation of this receptor has been found to induce marked increases in the intracellular calcium concentrations and Th-2 cytokines and chemokines release. This evidence and others discussed in this review provide an emerging view of Fc{epsilon}R/IgE network as a critical modulator of ASM cell function in allergic asthma.




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