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Am J Physiol Lung Cell Mol Physiol (February 8, 2002). doi:10.1152/ajplung.00037.2001
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Articles in PresS, published online ahead of print February 8, 2002
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00037.2001
Submitted on February 21, 2001
Accepted on February 1, 2002

DISTINCT PATTERNS OF APOPTOSIS IN THE LUNG DURING LIQUIDVENTILATION COMPARED TO GAS VENTILATION

Lin L Mantell1*, Thomas H Shaffer2, Stuart Horowitz3, Ray Foust III2, Marla Wolfson2, Cindy R Cox2, Poonam Khullar4, Zahra Zakeri5, Lin Lin5, Jeffrey A Kazzaz6, Tom Palaia6, William Scott7, and Jonathan M Davis8

1 CardioPulmonary Research Institute, Winthrop University Hospital, SUNY Stony BrookSchool of Medicine, Mineola, NY, USA; Thoracic Cardiovascular Surgery, Winthrop University Hospital,SUNY Stony Brook School of Medicine, Mineola, NY, USA; Pediatrics, Winthrop University Hospital, SUNY Stony Brook School of Medicine, Mineola, NY, USA
2 Department of Physiology, Temple UniversitySchool of Medicine, Philadelphia, PA, USA
3 Heart and Lung Institute, Jewish Hospital, Louisville, KY, USA
4 Pediatrics, Winthrop University Hospital, SUNY Stony Brook School of Medicine, Mineola, NY, USA
5 Department of Biology, Queens College, New York, NY, USA
6 CardioPulmonary Research Institute, Winthrop University Hospital, SUNY Stony BrookSchool of Medicine, Mineola, NY, USA
7 Thoracic Cardiovascular Surgery, Winthrop University Hospital,SUNY Stony Brook School of Medicine, Mineola, NY, USA
8 Pediatrics, Winthrop University Hospital, SUNY Stony Brook School of Medicine, Mineola, NY, USA; CardioPulmonary Research Institute, Winthrop University Hospital, SUNY Stony BrookSchool of Medicine, Mineola, NY, USA

* To whom correspondence should be addressed. E-mail: lmantell{at}winthrop.org.

To determine whether liquid ventilation (LV)causes less cell injury and improves lung function compared to conventional gas ventilation (GV), pulmonary physiological profiles, lung histology and cell death were analyzed in 110 and 120 day preterm lambs. While LV lungs were well expanded with adequate pulmonary function, GV animals exhibited marked atelectasis, poor pulmonary function and increased mortality. Both ventilatory strategies induced marked lung cell apoptosis, but with distinct patterns of distribution. While GV induced apoptosis of epithelium primarily in the lining and within the lumina of bronchioles, LV induced significant apoptosis much more homogenously throughout lung parenchyma including alveoli and interstitium spaces. The marked apoptosis in LV lungs suggests that LV may induce significant lung injury, which must be considered carefully before LV is used routinely in clinical practice.




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