AJP - Lung Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol (August 9, 2002). doi:10.1152/ajplung.00066.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/5/L1086    most recent
00066.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (19)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DANAN, C.
Right arrow Articles by DELACOURT, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DANAN, C.
Right arrow Articles by DELACOURT, C.

Articles in PresS, published online ahead of print August 9, 2002
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00066.2002
Submitted on February 21, 2002
Accepted on July 11, 2002

Gelatinase activities in the airways of premature infants and development of bronchopulmonary dysplasia

Claude DANAN1, Pierre-Henri JARREAU2, Marie-Laure FRANCO3, Gilles DASSIEU1, Christophe GRILLON1, Issam ABD ALSAMAD2, Chantal LAFUMA3, Alain HARF3, and Christophe DELACOURT3*

1 Unite de reanimation neonatale, Centre Hospitalier Intercommunal, Creteil, France
2 Service d'Anatomopathologie, Centre Hospitalier Intercommunal, Creteil, France
3 Faculte de Medecine, INSERM U492, Creteil, France

* To whom correspondence should be addressed. E-mail: christophe.delacourt{at}creteil.inserm.fr.

Matrix-degrading metalloproteinases may play a role in the pathophysiology of bronchopulmonary dysplasia (BDP). We therefore evaluated correlations between gelatinase activities (Metalloproteinase (MMP)-2 and MMP-9) or tissue inhibitor of metalloproteinase (TIMP)-1 levels present in the airways during the initial phase of hyaline membrane disease and the onset of BPD. Tracheal aspirates were obtained within 6 hours of birth (day 0) from 64 intubated neonates with a gestational age of 30 weeks or less. Forty-five neonates were resampled on day 3 or day 5. Total MMP-2 level measured by zymography fell with time, whereas total MMP-9 level and TIMP-1 levels, assayed by ELISA, increased; the MMP-9 increase correlated with the increase in airway inflammatory cell numbers. Among the parameters measured on day 0, day 3, or day 5, lower total MMP-2 level on day 0, lower birth weight and higher FiO2 on day 0 were significantly and independently associated with the development of BPD. Conclusions. MMP-9 level and TIMP-1 levels increased after birth but are not linked to BPD outcome. In contrast, low MMP-2 level at birth is strongly associated with the development of BPD.




This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
K. J. Greenlee, Z. Werb, and F. Kheradmand
Matrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted
Physiol Rev, January 1, 2007; 87(1): 69 - 98.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
O. Altiok, R. Yasumatsu, G. Bingol-Karakoc, R. J. Riese, M. T. Stahlman, W. Dwyer, R. A. Pierce, D. Bromme, E. Weber, and S. Cataltepe
Imbalance between Cysteine Proteases and Inhibitors in a Baboon Model of Bronchopulmonary Dysplasia
Am. J. Respir. Crit. Care Med., February 1, 2006; 173(3): 318 - 326.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
I. I. Ekekezie, D. W. Thibeault, S. D. Simon, M. Norberg, J. D. Merrill, R. A. Ballard, P. L. Ballard, and W. E. Truog
Low Levels of Tissue Inhibitors of Metalloproteinases With a High Matrix Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 Ratio Are Present in Tracheal Aspirate Fluids of Infants Who Develop Chronic Lung Disease
Pediatrics, June 1, 2004; 113(6): 1709 - 1714.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2002 by the American Physiological Society.