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Am J Physiol Lung Cell Mol Physiol (August 9, 2002). doi:10.1152/ajplung.00066.2002
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Articles in PresS, published online ahead of print August 9, 2002
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00066.2002
Submitted on February 21, 2002
Accepted on July 11, 2002

Gelatinase activities in the airways of premature infants and development of bronchopulmonary dysplasia

Claude DANAN1, Pierre-Henri JARREAU2, Marie-Laure FRANCO3, Gilles DASSIEU1, Christophe GRILLON1, Issam ABD ALSAMAD2, Chantal LAFUMA3, Alain HARF3, and Christophe DELACOURT3*

1 Unite de reanimation neonatale, Centre Hospitalier Intercommunal, Creteil, France
2 Service d'Anatomopathologie, Centre Hospitalier Intercommunal, Creteil, France
3 Faculte de Medecine, INSERM U492, Creteil, France

* To whom correspondence should be addressed. E-mail: christophe.delacourt{at}creteil.inserm.fr.

Matrix-degrading metalloproteinases may play a role in the pathophysiology of bronchopulmonary dysplasia (BDP). We therefore evaluated correlations between gelatinase activities (Metalloproteinase (MMP)-2 and MMP-9) or tissue inhibitor of metalloproteinase (TIMP)-1 levels present in the airways during the initial phase of hyaline membrane disease and the onset of BPD. Tracheal aspirates were obtained within 6 hours of birth (day 0) from 64 intubated neonates with a gestational age of 30 weeks or less. Forty-five neonates were resampled on day 3 or day 5. Total MMP-2 level measured by zymography fell with time, whereas total MMP-9 level and TIMP-1 levels, assayed by ELISA, increased; the MMP-9 increase correlated with the increase in airway inflammatory cell numbers. Among the parameters measured on day 0, day 3, or day 5, lower total MMP-2 level on day 0, lower birth weight and higher FiO2 on day 0 were significantly and independently associated with the development of BPD. Conclusions. MMP-9 level and TIMP-1 levels increased after birth but are not linked to BPD outcome. In contrast, low MMP-2 level at birth is strongly associated with the development of BPD.




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