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Am J Physiol Lung Cell Mol Physiol (May 11, 2007). doi:10.1152/ajplung.00112.2007
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Submitted on March 23, 2007
Accepted on May 9, 2007

Regulation of Surfactant Secretion in Alveolar Type II cells

Alexandra V Andreeva1, Mikhail A Kutuzov1, and Tatyana A. Voyno-Yasenetskaya1*

1 Pharmacology, University of Illinois, Chicago, Illinois, United States

* To whom correspondence should be addressed. E-mail: tvy{at}uic.edu.

Molecular mechanisms of surfactant delivery to the air/liquid interface in the lung, which is crucial to lower the surface tension, have been studied for over two decades. Lung surfactant is synthesized in the alveolar type II cells. Its delivery to the cell surface is preceded by surfactant component synthesis, packaging into specialized organelles termed lamellar bodies, delivery to the apical plasma membrane and fusion. Secreted surfactant undergoes re-uptake, intracellular processing and finally re-secretion of recycled material. This review focuses on the mechanisms of delivery of surfactant components to and their secretion from lamellar bodies. Lamellar bodies-independent secretion is also considered. Signal transduction pathways involved in regulation of these processes are discussed, as well as disorders associated with their malfunction.




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