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1 Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
* To whom correspondence should be addressed. E-mail: David.Foster{at}utsouthwestern.edu.
Circulating erythropoietin (EPO) stimulates erythrocytosis while organ-specific local EPO receptor (EPOR) expression has been linked to angiogenesis, tissue growth and development. Based on the observation of concurrent enhancement of lung growth and erythrocyte production during exposure to chronic hypoxia, we hypothesized that a paracrine EPO system is involved in mediating lung growth. We analyzed EPOR protein expression in normal dog lung tissue during postnatal maturation and during compensatory lung growth following right pneumonectomy (PNX). Membrane-bound EPOR was significantly more abundant in the immature lung compared to mature lung, and in the remaining lung 3 wk after PNX compared to matched sham controls. C-terminal cytosolic EPOR peptides were significantly more abundant than membrane-bound EPOR and were also upregulated in immature lung but differentially processed after PNX. Apoptosis was increased during both types of lung growth in direct relationship to cellular proliferation and EPOR expression. We conclude that both developmental and compensatory lung growth involve paracrine EPO signaling with parallel upregulation but differential processing of EPOR.
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