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Am J Physiol Lung Cell Mol Physiol (August 10, 2007). doi:10.1152/ajplung.00120.2007
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Submitted on March 27, 2007
Accepted on August 6, 2007

Regulation of vascular endothelial cell barrier function and cytoskeleton structure by protein phosphatases of the PPP family

Csilla Csortos1, Irina Kolosova2, and Alexander D Verin3*

1 Department of, University of Debrecen, Debrecen, Hungary
2 Department of, Case Western Reserve University, Cleveland, Ohio, United States
3 Medicine, Medical College of Georgia, Augusta, Georgia, United States

* To whom correspondence should be addressed. E-mail: averin{at}mcg.edu.

Reversible phosphorylation of cytoskeletal and cytoskeleton-associated proteins is a significant element of endothelial barrier function regulation. Therefore, understanding the mechanisms of phosphorylation/dephosphorylation of endothelial cell cytoskeletal proteins is vital to the treatment of severe lung disorders such as high permeability pulmonary edema. In vivo, there is a controlled balance between the activities of protein kinases and phosphatases. Due to various external or internal signals, this balance may be shifted. The actual balances at a given time alter the phosphorylation level of certain proteins with appropriate physiological consequences. The latest information about the structure and regulation of different types of Ser/Thr protein phosphatases participating in the regulation of endothelial cytoskeletal organization and barrier function will be reviewed here.




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