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Am J Physiol Lung Cell Mol Physiol (September 20, 2002). doi:10.1152/ajplung.00138.2002
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Articles in PresS, published online ahead of print September 20, 2002
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00138.2002
Submitted on May 6, 2002
Accepted on August 29, 2002

INDUCTION OF ENDOTOXIN TOLERANCE IMPROVES LUNG FUNCTION AFTER WARM ISCHEMIA IN DOGS

Ivar Friedrich1*, Jan Spillner1, Er-Xiong Lu2, Markus Barnscheidt2, Oliver Kuss1, Armin Sablotzki2, Franz Ulrich Schade1, and Jochen Borgermann1

1 Thoracic and Cardiovascular Surgery, Martin-Luther-University Halle, Halle, Germany
2 Clinical Research Group Shock & MOF, Essen University, Essen, Germany

* To whom correspondence should be addressed. E-mail: ivar.friedrich{at}medizin.uni-halle.de.

Background: In shock models, induction of endotoxin tolerance (ET) is known to have a protective effect. The present study was designed to explore if ET is effective in protecting lungs from reperfusion injury. Methods: 12 Foxhounds were used as experimental animals. After a left thoracotomy, the left hilum was clamped for 3 h, followed by 8 h of reperfusion. In the treatment group (ET, n=6), dogs were pretreated with incremental daily lipopolysaccharide (LPS) doses of up to 60 µg/kg on day 6. The ischemia and reperfusion experiment was carried out on day 9. Control group animals(C, n=6) were not subjected to LPS. Results: After 8 hours of observation, functional parameters of the reperfused lung of the ET and the control group were statistically different(p<0.05) with respect to pO2 (ET vs. control mean ± SEM: 172.7 ± 12.9 vs. 66.1 ± 7.2 mmHg), compliance (16.0 ± 1.2 vs. 8.3 ± 1.0 ml/0.1kPa), and wet/dry ratio (9.4 ± 0.8 vs. 16.7 ± 1.2). Conclusion: After 3 h of warm ischemia and 8 h of reperfusion, pulmonary function and lung water content improved in the endotoxin tolerant group.






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