| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print January 4, 2002
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00139.2001
Submitted on April 20, 2001
Accepted on December 31, 1969
1 Anesthesiology and Medicine, VA San Diego Healthcare System, San Diego, CA, USA; Anesthesiology and Medicine, University of California, San Diego, San Diego, CA, USA
2 Pediatrics (Neonatology), SUNY University at Buffalo, Buffalo, NY, USA
3 Pediatrics (Neonatology), University of Rochester, Rochester, NY, USA
4 Anesthesiology and Medicine, VA San Diego Healthcare System, San Diego, CA, USA
5 Anesthesiology and Medicine, University of California, San Diego, San Diego, CA, USA; Anesthesiology and Medicine, VA San Diego Healthcare System, San Diego, CA, USA
* To whom correspondence should be addressed. E-mail: rhhastings{at}ucsd.edu.
Parathyroid hormone-related protein (PTHrP) is a growth inhibitor for alveolar type II cells. Type II cell proliferation after lung injury from 85% oxygen is regulated, in part, by a fall in lung PTHrP. In this study, we investigated lung PTHrP after injury induced by >95% oxygen in rats and rabbits. In adult rats, lung PTHrP rose 10-fold over controls to 6356 ± 710 pg/ml (mean ± SEM) at 48 h of hyperoxia. Levels fell to 299 ± 78 pg/ml and staining for PTHrP mRNA was greatly reduced at 60 h (P < 0.05), the point of most severe injury and greatest pneumocyte proliferation. In adult rabbits, lung PTHrP peaked at 3289 ± 230 pg/ml following 64 h hyperoxia with 24 h of normoxic recovery, then dropped to 1629 ± 153 pg/ml at 48 h of recovery (P < 0.05). Type II cell proliferation peaked shortly after the fall in PTHrP. In newborn rabbits, lavage PTHrP increased by 50% during the first eight days of hyperoxia while type II cell growth decreased. PTHrP declined at the LD50, concurrent with increased type II cell division. In summary, lung PTHrP initially rises after injury with >95% hyperoxia, then falls near the peak of injury. Changes in PTHrP are temporally related to type II cell proliferation and may regulate repair of lung injury.
This article has been cited by other articles:
|
|
 |
|
  R. H. Hastings, R. A. Quintana, R. Sandoval, D. Duey, Y. Rascon, D. W. Burton, and L. J. Deftos Proapoptotic Effects of Parathyroid Hormone-Related Protein in Type II Pneumocytes Am. J. Respir. Cell Mol. Biol., December 1, 2003; 29(6): 733 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. Hastings, R. A. Quintana, R. Sandoval, D. W. Burton, and L. J. Deftos Amino-terminal and midmolecule parathyroid hormone-related protein, phosphatidylcholine, and type II cell proliferation in silica-injured lung Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1312 - L1322. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
