AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol (April 28, 2006). doi:10.1152/ajplung.00157.2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
291/3/L307    most recent
00157.2006v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ware, L. B
Right arrow Articles by Matthay, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ware, L. B
Right arrow Articles by Matthay, M. A.
Submitted on April 24, 2006
Accepted on April 25, 2006

Bench to Bedside: Targeting Coagulation and Fibrinolysis in Acute Lung Injury

Lorraine B Ware1*, Eric Camerer2, Karen E Welty-Wolf3, Marcus J Schultz4, and Michael A. Matthay5

1 Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States
2 Cardiovascular Research Institute, UCSF, California, United States
3 Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, United States
4 Department of Intensive Care and Laboratory for Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
5 Cardiovascular Research Institute and Departments of Medicine and Anesthesia, UCSF, San Francisco, California, United States

* To whom correspondence should be addressed. E-mail: lorraine.ware{at}vanderbilt.edu.

Substantial progress has been made in understanding the contribution of alterations in coagulation and fibrinolysis to the pathogenesis of acute lung injury. Findings from mouse, rat, baboon and human studies indicate that alterations in coagulation and fibrinolysis may be of major pathogenetic importance in acute lung injury and other inflammatory conditions in the lung including pneumonia, sepsis and ventilator-induced lung injury. Therapies targeted at both activation of coagulation through the extrinsic coagulation cascade and modulation of coagulation through the protein C system have the potential to favorably impact clinical ALI/ARDS.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Shetty, J. Padijnayayveetil, T. Tucker, D. Stankowska, and S. Idell
The fibrinolytic system and the regulation of lung epithelial cell proteolysis, signaling, and cellular viability
Am J Physiol Lung Cell Mol Physiol, December 1, 2008; 295(6): L967 - L975.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. D. Rubenfeld and E. Abraham
When Is a Negative Phase II Trial Truly Negative?
Am. J. Respir. Crit. Care Med., September 15, 2008; 178(6): 554 - 555.
[Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. A. Richardson, A. Gupta, L. A. O'Brien, D. T. Berg, B. Gerlitz, S. Syed, G. R. Sharma, M. S. Cramer, J. G. Heuer, E. J. Galbreath, et al.
Treatment of Sepsis-Induced Acquired Protein C Deficiency Reverses Angiotensin-Converting Enzyme-2 Inhibition and Decreases Pulmonary Inflammatory Response
J. Pharmacol. Exp. Ther., April 1, 2008; 325(1): 17 - 26.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. S. Calfee and M. A. Matthay
Nonventilatory Treatments for Acute Lung Injury and ARDS
Chest, March 1, 2007; 131(3): 913 - 920.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2006 by the American Physiological Society.