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Am J Physiol Lung Cell Mol Physiol (August 9, 2002). doi:10.1152/ajplung.00180.2002
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Articles in PresS, published online ahead of print August 9, 2002
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00180.2002
Submitted on June 7, 2002
Accepted on August 2, 2002

Fibroblast Growth Factor-2 During Postnatal Development of the Tracheal Basement Membrane Zone

Michael J. Evans1*, Michelle V. Fanucchi1, Laura S. Van Winkle1, Gregory L. Baker1, April E. Murphy1, Susan J. Nishio1, Philip L. Sannes2, and Charles G. Plopper1

1 Department of Anatomy, Physiology, & Cell Biology, University of California, Davis, School of Veterinary Medicine, Davis, CA, USA
2 Department of Anatomy, Physiological Sciences and Radiology, North Carolina State University, College of Veterinary Medicine, Raleigh, NC, USA

* To whom correspondence should be addressed. E-mail: mevans{at}ucdavis.edu.

Thickening of the basement membrane zone (BMZ) is a characteristic of several airway diseases, however very little is known about how this process occurs. The purpose of this study was to define development of the BMZ in the trachea of growing rhesus monkeys at 1, 2, 3 and 6 months of age. We measured immunoreactivity of collagen type I, III and V to detect structural changes in the developing BMZ. To detect more dynamic, functional components of the epithelial-mesenchymal trophic unit we evaluated the distribution of perlecan, fibroblast growth factor-2 (FGF-2) and fibroblast growth factor receptor-1 (FGFR-1). One month old monkeys had a mean collagen BMZ width of 1.5 ± 0.7 µm, that increased to 4.4 ± 0.4 µm in 6 month old monkeys. Perlecan was localized in the BMZ of the epithelium at all ages. FGF-2 was strongly expressed in basal cells at 1-3 months. At 6 months, FGF-2 was expressed throughout the BMZ and weakly in basal cells. FGFR-1 immunoreactivity was expressed by basal cells, cilia and weakly in the nuclei of columnar cells at all time points. These data indicate that development of the BMZ is a postnatal event in the rhesus monkey that involves FGF-2.




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