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Articles in PresS, published online ahead of print November 16, 2001
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00196.2001
Submitted on June 5, 2001
Accepted on October 15, 2001
1 MRC Centre For Developmental Neurobiology, King's College London, London, United Kingdom
* To whom correspondence should be addressed. E-mail: matthew.hind{at}kcl.ac.uk.
Endogenous retinoids have been implicated in alveologenesis in both the rat and the mouse and exogenous RA can reverse or partially reverse experimental emphysema in adult rat and mouse models by an unknown mechanism. In these studies we examine the cellular and molecular biology of retinoid signalling during alveologenesis in the mouse. We describe the temporal and spatial expression of the retinoid binding proteins CRBP-I, CRBP-II, and CRABP-I using RT-PCR and immunohistochemistry. We identify the retinoic acid receptor isoforms RAR
1, RARß2, RARß4 and RAR
2 and describe their temporal and spatial expression using RT-PCR and in situ hybridisation. We demonstrate that both retinoid binding proteins and retinoic acid receptor isoforms are temporally regulated and found within the alveolar septal regions during alveologenesis. These data support a role of dynamic endogenous RA signalling during alveolar formation.
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