| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA
2 Department of Pediatrics, University of Rochester, Rochester, NY, USA
* To whom correspondence should be addressed. E-mail: brs2{at}pitt.edu.
Identification of early events that contribute to the establishment of chronic lung disease have been complicated by the variable involvement of the airway and alveolar compartments in the complex physiology of end-stage disease. In particular, the impact of airway injury on alveolar integrity and function has not been addressed and would be facilitated by development of animal models of lung disease that specifically target a single cell type within the airway epithelium. We have previously demonstrated that ganciclovir treatment of CCtk transgenic mice, which express the herpes simplex thymidine kinase gene under regulation of the mouse CCSP promoter, results in elimination of the airway progenitor and stem cell pools, and a consequent failure of airway regeneration that is associated with rapid morbidity and mortality. In this study, we have used the CCtk model to test the hypothesis that selective airway injury initiates profound lung dysfunction through mechanisms that compromise alveolar integrity. Results demonstrate that elimination of the CCSP-expressing cell population results in secondary alveolar inflammation, edema, and depletion of the alveolar type 2 cell population. Based on these data we conclude that selective airway injury can serve as the inciting injury in diseases characterized by severely compromised alveolar function.
This article has been cited by other articles:
|
|
 |
|
  D.M. Raiser, S.J. Zacharek, R.R. Roach, S.J. Curtis, K.W. Sinkevicius, D.W. Gludish, and C.F. Kim Stem Cell Biology in the Lung and Lung Cancers: Employing Pulmonary Context and Classic Approaches Cold Spring Harb Symp Quant Biol, November 26, 2008; (2008) sqb.2008.73.036v2. [Abstract] [PDF]
|
|
|
|
 |
|
 J. S. Dovey, S. J. Zacharek, C. F. Kim, and J. A. Lees Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion PNAS, August 19, 2008; 105(33): 11857 - 11862. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Warburton, L. Perin, R. DeFilippo, S. Bellusci, W. Shi, and B. Driscoll Stem/Progenitor Cells in Lung Development, Injury Repair, and Regeneration Proceedings of the ATS, August 15, 2008; 5(6): 703 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Rippon, S. Lane, M. Qin, N.-S. Ismail, M. R. Wilson, M. Takata, and A. E. Bishop Embryonic Stem Cells as a Source of Pulmonary Epithelium In Vitro and In Vivo Proceedings of the ATS, August 15, 2008; 5(6): 717 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Wong, A. E. Dutly, A. Sacher, H. Lee, D. M. Hwang, M. Liu, S. Keshavjee, J. Hu, and T. K. Waddell Targeted cell replacement with bone marrow cells for airway epithelial regeneration Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L740 - L752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C M Doerschuk Circulating endothelial progenitor cells in pulmonary inflammation Thorax, May 1, 2005; 60(5): 362 - 364. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
