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Am J Physiol Lung Cell Mol Physiol (March 22, 2002). doi:10.1152/ajplung.00204.2001
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Articles in PresS, published online ahead of print March 22, 2002
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00204.2001
Submitted on June 6, 2001
Accepted on March 12, 2002

Possible Role of Adipocyte Differentiation-Related Protein in Lung Surfactant Phospholipid Synthesis by Epithelial Type II Cells

C. J Schultz1, E. Torres1, C. Londos2*, and J. S Torday2

1 Laboratory of Cellular and Developmental Biology, National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA
2 Departments of Pediatrics and Obstetrics and Gynecology, University of California at Los Angeles, Harbor-UCLA Medical Center Research and Education Institute, Los Angeles, CA, USA

* To whom correspondence should be addressed. E-mail: DeanL{at}intra.niddk.nih.gov.

Adipocyte differentiation related protein (ADRP) is an intrinsic lipid storage droplet protein that is highly expressed in lung. ADRP localizes to lipid storage droplets within lipofibroblasts, pulmonary cells characterized by high triacylglycerol, which is a precursor for surfactant phospholipid synthesis by alveolar Type II (ATII) cells. are The developmental pattern of ADRP mRNA and protein expression in lung tissue parallels triacylglycerol accumulation in rat lung. ADRP mRNA levels are relatively high in isolated lipofibroblasts, accounting for the high ADRP expression in lung. Isolated ATIIs, which do not store neutral lipids but derive them from lipofibroblasts, have low levels of ADRP mRNA expression. ADRP is found around lipid droplets in cultured lipofibroblasts, but not in ATIIs isolated from developing rat lung. After coculture with lipofibroblasts ATII cells acquired ADRP , which associates with lipid droplets. Furthermore, [3H]-labeled triolein in isolated ADRP-coated lipid droplets is a ten-fold better substrate for surfactant phospholipid synthesis by cultured ATIIs than [3H]-labeled synthetic triolein alone. Antibodies to ADRP block transfer of neutral lipid. These data suggest a role for ADRP in this novel mechanism for the transfer of lipid between lipofibroblasts and ATIIs.




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