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Articles in PresS, published online ahead of print October 26, 2001
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00207.2001
Submitted on June 6, 2001
Accepted on October 15, 2001
1 Pediatrics, University of Maryland, Baltimore, MD, USA
2 Physiology, Johns Hopkins University, Baltimore, MD, USA
3 Pediatric Pulmonary, Johns Hopkins University, Baltimore, MD, USA; Physiology, Johns Hopkins University, Baltimore, MD, USA
* To whom correspondence should be addressed. E-mail: cblaisdell{at}peds.umaryland.edu.
Chloride transport is critical to many functions of the lung. Molecular defects in the best-known chloride channel, cystic fibrosis transmembrane conductance regulator (CFTR), lead to impaired function of airway defensins, hydration of airway surface fluid and mucociliary clearance leading to chronic lung disease, and premature death, but do not cause defects in lung development. We examined the expression of one member of the ClC family of volume and voltage regulated channels using the ribonuclease protection assay and Western blot analysis in rat. ClC-5 mRNA and protein are most strongly expressed in the fetal lung, and expression is maintained though downregulated postnatally. In addition, using immunocytochemistry, we find that ClC-5 is predominantly expressed along the luminal surface of the airway epithelium, suggesting that ClC-5 may participate in lung chloride secretion. Identifying candidate genes for critical ion transport functions is essential for understanding normal lung morphogenesis and the pathophysiology of several lung diseases. In addition, the manipulation of non-CFTR chloride channels may provide a viable approach for treating CF lung disease.
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