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Articles in PresS, published online ahead of print July 12, 2002
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00266.2001
Submitted on July 17, 2001
Accepted on June 26, 2002
1 Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
2 Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA
* To whom correspondence should be addressed. E-mail: Kathleen_Veness-Meehan{at}med.unc.edu.
Exposure of the newborn lung to hyperoxia is associated with impaired alveolar development. In newborn rats exposed to hyperoxia and studied at d 14 of life, retinoic acid (RA) treatment improved survival and increased lung collagen but did not improve alveolar development. To determine whether RA treatment during exposure to hyperoxia results in late improvement in alveolarization, we treated newborn rats with RA and hyperoxia from d 3 to d 14, then weaned O2 to room air by d 20, and studied the animals on d 42. Oxygen-exposed animals had larger mean lung volumes, larger alveoli, and decreased gas-exchange tissue relative to air-exposed controls, while RA treated oxygen-exposed animals were not statistically different from air-exposed controls. Relative to control animals, elastin staining at d 14 was decreased in hyperoxia-exposed lung independent of RA treatment and at d 42, elastin staining was similar in all treatment groups. At d 14 elastin gene expression was similar in all treatment groups while at d 42 lung previously exposed to hyperoxia showed increased elastin signal independent of RA treatment. These results indicate that RA treatment during hyperoxia exposure promotes septal formation without evidence of effects on elastin gene expression following 4 weeks of recovery.
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