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Am J Physiol Lung Cell Mol Physiol (April 18, 2003). doi:10.1152/ajplung.00266.2002
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Submitted on August 6, 2002
Accepted on April 16, 2003

{beta} -adrenergic agonists regulate the Na,K-ATPase via the p70s6K

Liuska Pesce1, Alejandro Comellas1, and Jacob I. Sznajder1*

1 Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, USA

* To whom correspondence should be addressed. E-mail: j-sznajder{at}northwestern.edu.

We have recently reported that the {beta}-adrenergic agonist, isoproterenol, regulates the alveolar epithelial cell Na,K-ATPase via MAPK/ERK and rapamycin-sensitive pathways. Here, we report that isoproterenol phosphorylated the p70s6K in alveolar epithelial cells, which was inhibited by both, rapamycin and the MEK1/2 inhibitor U0126. In alveolar epithelial cells transfected with a p70s6K dominant negative construct, isoproterenol did not increase Na,K-ATPase total protein expression, whereas in cells transfected with a rapamycin resistant mutant the isoproterenol-mediated increase in Na,K-ATPase was not prevented by rapamycin. Accordingly, we provide here first evidence that isoproterenol regulates the Na,K-ATPase via the p70s6K in alveolar epithelial cells.




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