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1 Department of Anesthesiology, University of California, San Francisco, San Francisco, CA, USA
2 Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA
3 Depatment of Surgery, University of California, San Francisco, San Francisco, CA, USA
4 Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA; The Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA
* To whom correspondence should be addressed. E-mail: leejw{at}anesthesia.ucsf.edu.
Neonates and infants with congenital heart disease with increased pulmonary blood flow suffer morbidity from poor oxygenation and decreased lung compliance. In a previous experiment involving 4 weeks old lambs with pulmonary hypertension secondary to increased pulmonary blood flow following an in utero placement of an aortopulmonary vascular graft, we found a decrease in surfactant protein A (SP-A) gene expression as well as a decrease in SP-A and surfactant protein B (SP-B) protein contents. To determine the timing of these changes, the objective of the current study was to characterize the effect of increased pulmonary blood flow and pulmonary hypertension on surfactant proteins A, B and C (SP-C) gene expressions and protein contents within the first week of life. Of eight fetal lambs that underwent the in utero placement of the shunt, there was no difference in the expression of SP-A, SP-B and SPC mRNA levels or SP-A and SP-B protein contents as compared to age-matched controls. The results showed that in this model of congenital heart disease with pulmonary hypertension and increased pulmonary blood flow, the effect of the shunt on surfactant protein gene expression and protein content was not apparent within the first week of life.
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