| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Divisions of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
* To whom correspondence should be addressed. E-mail: jeff.whitsett{at}cchmc.org.
In order to assess the role of FGF-signaling (fibroblast growth factor) in pulmonary function in the postnatal period, we generated transgenic mice in which a soluble FGF receptor (FGFR-HFc) was conditionally expressed in respiratory epithelial cells of the mouse lung, thereby inhibiting FGF activity. While FGFR-HFc did not alter postnatal lung morphogenesis, male FGFR-HFc transgenic mice were more susceptible to hyperoxia and failed to recover when ambient oxygen concentrations were normalized. Inflammation, alveolar-capillary leak, and mortality were increased following exposure to 95% FiO2. Expression of surfactant proteins, SP-A and SP-B were significantly decreased in association with decreased immunostaining for thyroid transcription factor-1 (TTF-1). FGF-signaling is required for maintenance of surfactant homeostasis and lung function during hyperoxia in vivo, mediated, at least in part, by its role in the maintenance of surfactant protein-B expression.
This article has been cited by other articles:
|
|
 |
|
  V. V. Gupte, S. K. Ramasamy, R. Reddy, J. Lee, P. H. Weinreb, S. M. Violette, A. Guenther, D. Warburton, B. Driscoll, P. Minoo, et al. Overexpression of Fibroblast Growth Factor-10 during Both Inflammatory and Fibrotic Phases Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice Am. J. Respir. Crit. Care Med., September 1, 2009; 180(5): 424 - 436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Wright, T. Zhuang, P. La, G. Yang, and P. A. Dennery Hyperoxia-induced NF-{kappa}B activation occurs via a maturationally sensitive atypical pathway Am J Physiol Lung Cell Mol Physiol, March 1, 2009; 296(3): L296 - L306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Borchers, S. C. Wesselkamper, B. L. Eppert, G. T. Motz, M. A. Sartor, C. R. Tomlinson, M. Medvedovic, and J. W. Tichelaar Nonredundant Functions of {alpha}{beta} and {gamma}{delta} T Cells in Acrolein-Induced Pulmonary Pathology Toxicol. Sci., September 1, 2008; 105(1): 188 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pagano, I. Metrailler-Ruchonnet, M. Aurrand-Lions, M. Lucattelli, Y. Donati, and C. B. Argiroffo Poly(ADP-ribose) polymerase-1 (PARP-1) controls lung cell proliferation and repair after hyperoxia-induced lung damage Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L619 - L629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ramos, M. Montano, C. Becerril, J. Cisneros-Lira, L. Barrera, V. Ruiz, A. Pardo, and M. Selman Acidic fibroblast growth factor decreases {alpha}-smooth muscle actin expression and induces apoptosis in human normal lung fibroblasts Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L871 - L879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Whitsett, C. J. Bachurski, K. C. Barnes, P. A. Bunn Jr., L. M. Case, D. N. Cook, D. Crooks, M. W. Duncan, L. Dwyer-Nield, R. C. Elston, et al. Functional Genomics of Lung Disease Am. J. Respir. Cell Mol. Biol., August 1, 2004; 31(2/S1): S1 - S81. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
