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Am J Physiol Lung Cell Mol Physiol (September 26, 2003). doi:10.1152/ajplung.00315.2002
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Submitted on September 17, 2002
Accepted on September 22, 2003

Latent adenoviral infection induces the production of growth factors relevant to airway remodeling in COPD

Emiko Ogawa1*, W. Mark Elliott1, Fiona Hughes2, Thomas J. Eichholtz3, James C. Hogg1, and Shizu Hayashi1

1 McDonald Research Laboratory, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, B.C., Canada
2 RA Biology,, GlaxoSmithKline R&D, Stevenage, Herts, United Kingdom
3 Asthma Disease Biology, GlaxoSmithKline R&D, Stevenage, Herts, United Kingdom

* To whom correspondence should be addressed. E-mail: eogawa{at}mrl.ubc.ca.

Previous studies have shown an association between latent adenoviral infection with expression of the adenoviral E1A gene and chronic obstructive pulmonary disease (COPD). The present study focuses on how the adenoviral E1A gene could alter expression of growth factors by human bronchial epithelial (HBE) cells. The data show that connective tissue growth factor (CTGF) and transforming growth factor (TGF)-{beta}1 mRNA and protein expression were up-regulated in E1A positive HBE cells. Up-regulation of CTGF in this in vitro model was independent of TGF-{beta} secreted into the growth media. Comparison of E1A positive to E1A negative HBE cells showed that both expressed cytokeratin but only E1A positive cells expressed the mesenchymal markers, vimentin and {alpha}-smooth muscle actin. We conclude that latent infection of epithelial cells by adenovirus E1A could contribute to the airway remodeling in COPD by the viral E1A inducing TGF-{beta}1 and CTGF expression and shifting cells to a more mesenchymal phenotype.




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