AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol (March 7, 2003). doi:10.1152/ajplung.00319.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/1/L240    most recent
00319.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shimoda, K.
Right arrow Articles by Traber, D. L
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shimoda, K.
Right arrow Articles by Traber, D. L
Submitted on September 20, 2002
Accepted on February 28, 2003

Effect of poly (ADP-ribose) synthetase inhibition on burn and smoke inhalation injury in sheep

Katsumi Shimoda1, Kazunori Murakami1, Perenlei Enkhbaatar1, Lillian D. Traber1, Robert A. Cox2, Hal K. Hawkins2, Frank C. Schmalstieg3, Katalin Komjati4, Jon G. Mabley4, Csaba Szabo4, Andrew L Salzman4, and Daniel L Traber1*

1 Department of Anesthesiology, University of Texas Medical Branch and Shriners Burns Hospital, Galveston, Tx, USA
2 Department of Pathology, University of Texas Medical Branch and Shriners Burns Hospital, Galveston, Tx, USA
3 Department of Pediatrics, University of Texas Medical Branch and Shriners Burns Hospital, Galveston, Tx, USA
4 Inotek Pharmaceuticals Corporation, Beverly, MA, USA

* To whom correspondence should be addressed. E-mail: dltraber{at}UTMB.EDU.

We investigated the role of the nuclear enzyme poly (ADP-ribose) synthetase (PARS) in the pathogenesis of combined burn and smoke inhalation (burn/smoke) injury in an ovine model. Eighteen sheep were operatively prepared for chronic study. PARS inhibition was achieved by treatment with a novel and selective PARS inhibitor, INO-1001. The PARS inhibitor attenuated (1) lung edema formation, (2) deterioration of gas exchange, (3) changes in airway blood flow, (4) changes in airway pressure, (5) lung histological injury and (6) systemic vascular leakage. Lipid oxidation and plasma NO2-/NO3- (stable breakdown products of nitric oxide) levels were suppressed by INO-1001. We conclude that PARS inhibition attenuates various aspects of the pathophysiological response in a clinically relevant experimental model of burn/smoke inhalation injury.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
O. L. Syrkina, D. A. Quinn, W. Jung, B. Ouyang, and C. A. Hales
Inhibition of JNK activation prolongs survival after smoke inhalation from fires
Am J Physiol Lung Cell Mol Physiol, April 1, 2007; 292(4): L984 - L991.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
C. L. Cheng, S. P. Johnson, S. T. Keir, J. A. Quinn, F. Ali-Osman, C. Szabo, H. Li, A. L. Salzman, M. E. Dolan, P. Modrich, et al.
Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft
Mol. Cancer Ther., September 1, 2005; 4(9): 1364 - 1368.
[Abstract] [Full Text] [PDF]

Home page
 TraumaHome page
L. C Cancio
Current concepts in the pathophysiology and treatment of inhalation injury
Trauma, January 1, 2005; 7(1): 19 - 35.
[Abstract] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
P. Pacher, A. Vaslin, R. Benko, J. G. Mabley, L. Liaudet, G. Hasko, A. Marton, S. Batkai, M. Kollai, and C. Szabo
A New, Potent Poly(ADP-ribose) Polymerase Inhibitor Improves Cardiac and Vascular Dysfunction Associated with Advanced Aging
J. Pharmacol. Exp. Ther., November 1, 2004; 311(2): 485 - 491.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.