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Am J Physiol Lung Cell Mol Physiol (March 7, 2003). doi:10.1152/ajplung.00319.2002
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Submitted on September 20, 2002
Accepted on February 28, 2003

Effect of poly (ADP-ribose) synthetase inhibition on burn and smoke inhalation injury in sheep

Katsumi Shimoda1, Kazunori Murakami1, Perenlei Enkhbaatar1, Lillian D. Traber1, Robert A. Cox2, Hal K. Hawkins2, Frank C. Schmalstieg3, Katalin Komjati4, Jon G. Mabley4, Csaba Szabo4, Andrew L Salzman4, and Daniel L Traber1*

1 Department of Anesthesiology, University of Texas Medical Branch and Shriners Burns Hospital, Galveston, Tx, USA
2 Department of Pathology, University of Texas Medical Branch and Shriners Burns Hospital, Galveston, Tx, USA
3 Department of Pediatrics, University of Texas Medical Branch and Shriners Burns Hospital, Galveston, Tx, USA
4 Inotek Pharmaceuticals Corporation, Beverly, MA, USA

* To whom correspondence should be addressed. E-mail: dltraber{at}UTMB.EDU.

We investigated the role of the nuclear enzyme poly (ADP-ribose) synthetase (PARS) in the pathogenesis of combined burn and smoke inhalation (burn/smoke) injury in an ovine model. Eighteen sheep were operatively prepared for chronic study. PARS inhibition was achieved by treatment with a novel and selective PARS inhibitor, INO-1001. The PARS inhibitor attenuated (1) lung edema formation, (2) deterioration of gas exchange, (3) changes in airway blood flow, (4) changes in airway pressure, (5) lung histological injury and (6) systemic vascular leakage. Lipid oxidation and plasma NO2-/NO3- (stable breakdown products of nitric oxide) levels were suppressed by INO-1001. We conclude that PARS inhibition attenuates various aspects of the pathophysiological response in a clinically relevant experimental model of burn/smoke inhalation injury.




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