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1 Department of Pediatrics, National Jewish Medical & Research Center, Denver, Colorado, United States
2 Medicine, University of Colorado at Denver & Health Sciences Center, Denver, Colorado, United States
* To whom correspondence should be addressed. E-mail: hensonp{at}njc.org.
Apoptosis and other forms of programmed cell death are important contributors to lung pathophysiology. In this brief review we discuss some of the implications of finding apoptotic cells in the lung and methods for their detection. The balance between induction of apoptosis and the normally highly efficient clearance of such cells shows that these are highly dynamic processes and suggests that abnormalities of apoptotic cell clearance may be an alternative explanation for their detection. Since recognition of apoptotic cells by other lung cells has additional effects on inflammation, immunity, and tissue repair, local response to the dying cells may also have important consequences in addition to the cell death itself.
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