AJP - Lung Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol (February 28, 2003). doi:10.1152/ajplung.00322.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/1/L114    most recent
00322.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Borchers, M. T.
Right arrow Articles by Lee, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Borchers, M. T.
Right arrow Articles by Lee, J. J.
Submitted on September 25, 2002
Accepted on February 24, 2003

Methacholine-induced airway hyperresponsiveness is dependent on G{alpha}q signaling

Michael T. Borchers1, Travis Biechele1, Joshua P. Justice1, Tracy L. Ansay1, Stephania Cornier1, Valeria Mancino2, Thomas M. Wilkie3, Melvin I. Simon2, Nancy A. Lee1, and James J. Lee1*

1 Department of Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, AZ, USA
2 Division of Biology, California Institute of Technology, Pasadena, CA, USA
3 Department of Pharmacology, UT Southwestern, Dallas, TX, USA

* To whom correspondence should be addressed. E-mail: jlee{at}mayo.edu.

Airway function in health and disease as well as in response to bronchospastic stimuli (i.e., irritants, allergens and inflammatory mediators) is controlled, in part, by cholinergic muscarinic receptor regulation of smooth muscle. In particular, the dependence of airway smooth muscle contraction/relaxation on heterotrimeric G protein-coupled receptor signaling suggests that these events underlie the responses regulating airway function. G{alpha}q containing G-proteins are proposed to be a prominent signaling pathway and the availability of knockout mice deficient of this subunit has allowed for an investigation of its potential role in airway function. Airway responses in G{alpha}q deficient mice, assessing activity by both tracheal tension and in vivo lung function measurements, were attenuated relative to wild type controls. Moreover, ovalbumin sensitization/aerosol challenge of G{alpha}q deficient mice also failed to elicit an allergen-induced increase in airway reactivity to methacholine. These findings indicate that cholinergic receptor mediated responses are dependent on G{alpha}q-mediated signaling events and identifies G{alpha}q as a potential target of preventative/intervening therapies for lung dysfunction.




This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
R. B. Penn and J. L. Benovic
Regulation of Heterotrimeric G Protein Signaling in Airway Smooth Muscle
Proceedings of the ATS, January 1, 2008; 5(1): 47 - 57.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y. Ma, K. T. HayGlass, A. B. Becker, Y. Fan, X. Yang, S. Basu, G. Srinivasan, F. E. R. Simons, A. J. Halayko, and Z. Peng
Novel Recombinant Interleukin-13 Peptide-based Vaccine Reduces Airway Allergic Inflammatory Responses in Mice
Am. J. Respir. Crit. Care Med., September 1, 2007; 176(5): 439 - 445.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
N. Wettschureck and S. Offermanns
Mammalian G Proteins and Their Cell Type Specific Functions
Physiol Rev, October 1, 2005; 85(4): 1159 - 1204.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.