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1 Department of Anatomy, Physiology, and Cell Biology, University of California Davis, Davis, CA, USA
2 Department of Medicine, Division of Clinical Immunology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
* To whom correspondence should be addressed. E-mail: amyers{at}jhmi.edu.
In vitro antigen challenge has multiple effects on the excitability of guinea pig bronchial parasympathetic ganglion neurons including depolarization, causing phasic neurons to fire with a repetitive action potential pattern, and potentiating synaptic transmission. In the present study, guinea pigs were passively sensitized to the antigen, ovalbumin; following sensitization, the bronchi were prepared for in vitro electrophysiological intracellular recording of parasympathetic ganglia neurons in order to investigate the contribution of cyclooxygenase activation and prostanoids on parasympathetic nerve activity. Cyclooxygenase inhibition with either indomethacin or piroxicam prior to in vitro antigen challenge blocked the change in accommodation. These cyclooxygenase inhibitors also blocked the release of PGD2 from bronchial tissue during antigen challenge. We also determined that PDE2 and PGD2 decrease the duration of the action potential afterhyperpolarization while PGF2
potentiated synaptic transmission. Thus, prostaglandins released during antigen challenge have multiple effects on the excitability of guinea pig bronchial parasympathetic ganglia neurons which may consequently affect the output from these neurons and thereby alter parasympathetic tone in the lower airways.
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