AJP - Lung Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol (March 1, 2006). doi:10.1152/ajplung.00385.2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
291/2/L191    most recent
00385.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yin, Z.
Right arrow Articles by Morrisey, E. E
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yin, Z.
Right arrow Articles by Morrisey, E. E
Submitted on September 8, 2005
Accepted on February 21, 2006

Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression

Zhan Yin1, Linda Gonzales1, Venkatadri Kolla1, Nibedita Rath1, Yuzhen Zhang1, Min Min Lu1, Shioko Kimura2, Philip L Ballard3, Michael F Beers1, Jonathan A Epstein4, and Edward E Morrisey4*

1 Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
2 National Cancer Institute, Laboratory of Metabolism, National Institutes of Health, Bethesda, MD, USA
3 Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA
4 Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA

* To whom correspondence should be addressed. E-mail: emorrise{at}mail.med.upenn.edu.

Hop is an unusual homeodomain protein that was first identified in the developing heart where it functions downstream of Nkx2.5 to modulate cardiac gene expression. Hop functions through interactions with HDAC2 to mediate repression of cardiac specific genes and recent studies show that HDAC activity and HDAC2 expression are decreased in people with chronic obstructive pulmonary disease. Here, we show that Hop is expressed in airway epithelium coincident with HDAC2, and expression is induced by the combination of dexamethasone and cAMP in parallel with induction of surfactant protein gene expression. Hop functions in the developing pulmonary airway, acting downstream of Nkx2.1 and GATA6, to negatively regulate surfactant protein expression. Loss of Hop expression in vivo results in defective type 2 pneumocyte development with increased surfactant production and disrupted alveolar formation. Thus, Hop represents a novel regulator of pulmonary maturation that is induced by glucocorticoids to mediate functionally important HDAC-dependent negative feedback regulation.




This article has been cited by other articles:


Home page
 Mol Cancer ResHome page
K. Yamashita, M. S. Kim, H. L. Park, Y. Tokumaru, M. Osada, H. Inoue, M. Mori, and D. Sidransky
HOP/OB1/NECC1 Promoter DNA Is Frequently Hypermethylated and Involved in Tumorigenic Ability in Esophageal Squamous Cell Carcinoma
Mol. Cancer Res., January 1, 2008; 6(1): 31 - 41.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
W. Shu, M. M. Lu, Y. Zhang, P. W. Tucker, D. Zhou, and E. E. Morrisey
Foxp2 and Foxp1 cooperatively regulate lung and esophagus development
Development, May 15, 2007; 134(10): 1991 - 2000.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. G. Ackerman, J. Wang, L. Luo, Y. Fujiwara, S. H. Orkin, and D. R. Beier
Gata4 Is Necessary for Normal Pulmonary Lobar Development
Am. J. Respir. Cell Mol. Biol., April 1, 2007; 36(4): 391 - 397.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
Y. Maeda, V. Dave, and J. A. Whitsett
Transcriptional Control of Lung Morphogenesis
Physiol Rev, January 1, 2007; 87(1): 219 - 244.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2006 by the American Physiological Society.