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Am J Physiol Lung Cell Mol Physiol (November 3, 2006). doi:10.1152/ajplung.00386.2006
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Submitted on September 28, 2006
Accepted on October 30, 2006

Cell-cell adhesion in lung endothelium

D. Michael Shasby1*

1 Department of Internal Medicine, Pulmonary Division, University of Iowa College of Medicine, Iowa City, Iowa, United States

* To whom correspondence should be addressed. E-mail: shasby{at}blue.weeg.uiowa.edu.

Homotypic cell-cell adhesion is essential for tissue and organ development, remodeling and regeneration and physiologic function. While a significant number of homotypic cell-cell adhesion molecules have been identified, much more is know about those concentrated in epithelia than in endothelia. Among the endothelial cell-cell adhesion molecules, very little is known that is specific to endothelium in the pulmonary and bronchial circulations. This review focuses primarily on homotypic cell-cell adhesion molecules that are or are likely to be important in lung endothelium.




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