| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
1 Lawson Health Research Institute, London, ON, Canada; Departments of Physiology and Pharmacology, The University of Western Ontario, London, ON, Canada; Department of Medicine, The University of Western Ontario, London, ON, Canada
* To whom correspondence should be addressed. E-mail: rveldhui{at}uwo.ca.
Sepsis can predispose the lung to insults such as mechanical ventilation (MV). It was hypothesized that treating the lung with exogenous surfactant early in the development of sepsis will reduce the lung dysfunction associated with MV, 18 hrs later. Mice underwent sham or cecal ligation and perforation (CLP) surgery. Immediately after surgery, mice were either untreated or given 100mg/kg of Bovine Lipid Extract Surfactant (BLES) intratracheally. Eighteen hours later, the lungs were removed and either analyzed immediately or following ventilation ex vivo for 2 hrs using an "njurious" mode of ventilation(20ml/kg, 0cm PEEP). In non-ventilated lungs exogenous surfactant had no impact on compliance or IL-6 concentrations in the lungs. In the ventilated groups the administered surfactant had a significant protective effect on the lung dysfunction induced by mechanical ventilation, but only in the CLP lungs. We conclude that administration of exogenous surfactant at the time of a systemic insult can protect the lung from the damaging effects of mechanical ventilation 18hrs later.
This article has been cited by other articles:
|
|
 |
|
  M. R. Wilson, K. P. O'Dea, D. Zhang, A. D. Shearman, N. van Rooijen, and M. Takata Role of Lung-marginated Monocytes in an In Vivo Mouse Model of Ventilator-induced Lung Injury Am. J. Respir. Crit. Care Med., May 15, 2009; 179(10): 914 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. van Putte, P. M. Cobelens, N. van der Kaaij, B. Lachmann, A. Kavelaars, C. J. Heijnen, and J. Kesecioglu Exogenous surfactant attenuation of ischemia-reperfusion injury in the lung through alteration of inflammatory and apoptotic factors J. Thorac. Cardiovasc. Surg., April 1, 2009; 137(4): 824 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Martin, T. A. Sheikh, K. J. Leco, J. F. Lewis, and R. A. W. Veldhuizen Contribution of alveolar macrophages to the response of the TIMP-3 null lung during a septic insult Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L779 - L789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Martin, B. Z. Moyer, M. C. Pape, B. Starcher, K. J. Leco, and R. A. W. Veldhuizen Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1222 - L1232. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
