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Articles in PresS, published online ahead of print February 8, 2002
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00423.2001
Submitted on October 30, 2001
Accepted on February 1, 2002
* To whom correspondence should be addressed. E-mail: mbruce{at}pop.uky.edu.
Alveolarization is impaired in rats treated with Dexamethasone (Dex) from postnatal days 4-13, but concomitant treatment with all trans-retinoic acid (RA) increases alveolar number. To determine whether morphologic changes induced by Dex and/or RA predict changes in lung function at one month, we assessed resting breathing parameters, dynamic compliance, ventilation required to maintain oxygen saturation at 
90%, and pressure-volume curves of air-filled lungs. During resting breathing, tidal volume/g was greater in Dex+RA rats than controls (P<0.05). Dynamic compliance was also greater in Dex and Dex+RA versus controls or RA rats (P<0.02). In Dex and Dex+RA rats we observed increased air trapping(P<0.05), hysteresis ratios (P
0.006), and lung volumes at 5 and at 13.5 cm H2O pressure (P<0.001), and decreased elastic recoil (P<0.007). The effect of Dex on elastic recoil was greater in female than in male rats (P=0.006). Despite impaired septation, oxygen saturation was not compromised in Dex or Dex+RA rats. Thus, lung function changes induced by Dex treatment during alveolarization were not prevented by concomitant treatment with RA.
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