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Articles in PresS, published online ahead of print March 15, 2002
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00427.2001
Submitted on October 31, 2001
Accepted on March 8, 2002
1 Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
2 Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, OH, USA
* To whom correspondence should be addressed. E-mail: DPorter{at}cdc.gov.
In previous reports from this study, measurements of pulmonary inflammation, bronchoalveolar lavage (BAL) cell cytokine production and NF-
B activation, cytotoxic damage and fibrosis were detailed. In this study, we investigated the temporal relationship between silica inhalation, nitric oxide (NO) and reactive oxygen species (ROS) production, and damage mediated by these radicals, in the rat. Rats were exposed to a silica aerosol (15 mg/m3 silica, 6 hours/ day, 5 days/week) for 116 days. We report time-dependent changes in: (1) activation of alveolar macrophages (AM) and concomitant production of NO and ROS, (2) immunohistochemical localization of inducible nitric oxide synthase and NO-induced damage product nitrotyrosine, (3) BAL fluid NOx and superoxide dismutase concentrations, and (4) lung lipid peroxidation levels. The major observations made in this study are: (1) NO and ROS production and resultant damage increased during silica exposure, and (2) the sites of iNOS activation and NO-mediated damage are associated anatomically with pathological lesions in the lungs.
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