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Am J Physiol Lung Cell Mol Physiol (December 27, 2007). doi:10.1152/ajplung.00431.2007
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Submitted on October 18, 2007
Accepted on December 24, 2007

Amiloride-Insensitive Na+ and Fluid Absorption in the Mammalian Distal Lung

Hugh M. O'Brodovich1*, Peter Yang2, Shephali Gandhi2, and Gail Otulakowski3

1 Physiology and Experimental Medicine, Hospital for Sick Children Research Institute, Toronto, Canada; Paediatrics, University of Toronto, Toronto, Canada; Physiology, University of Toronto, Toronto, Canada
2 Physiology and Experimental Medicine, Hospital for Sick Children Research Institute, Toronto, Canada
3 Physiology and Experimental Medicine, Hospital for Sick Children Research Institute, Toronto, Canada; Paediatrics, University of Toronto, Toronto, Canada

* To whom correspondence should be addressed. E-mail: hugh.obrodovich{at}sickkids.ca.

The ability of the distal lung epithelia to actively transport Na+, with Cl- and water following, from the alveolar spaces inversely correlates with morbidity and mortality of infants, children and adults with alveolar pulmonary edema. It is now recognized, in contrast to many other Na+ transporting epithelia, that at least half of this active transport is not sensitive to amiloride which inhibits the epithelial Na+ channel (ENaC). This publication reviews amiloride-insensitive Na+ and fluid transport in the mammalian distal lung unit under basal conditions and speculates upon potential explanations for this amiloride-insensitive transport. It also provides new information, using primary cultures of rat fetal distal lung epithelia (FDLE) and alveolar type II (ATII) cells grown under submersion and air-liquid interface culture conditions, regarding putative blockers of this transport.




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