| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print February 15, 2002
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00438.2001
Submitted on November 12, 2001
Accepted on February 12, 2002
1 Pathology, Yale University School of Medicine, New Haven, CT, USA
2 Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
3 Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA
4 Pediatrics, Yale University School of Medicine, New Haven, CT, USA
* To whom correspondence should be addressed. E-mail: robert.homer{at}yale.edu.
IL-13, a key mediator of Th2 mediated immunity, contributes to the pathogenesis of asthma and other pulmonary diseases via its ability to generate fibrosis, mucus metaplasia, eosinophilic inflammation and airways hyperresponsiveness. In these studies we compared surfactant accumulation in wild type mice and mice in which IL-13 was overexpressed in the lung. When compared to littermate controls, light and electron microscopy showed alveolar type II cell hypertrophy in transgenic animals. Over time, their alveoli also filled with surfactant in a pulmonary alveolar proteinosis pattern. At the same time, prominent interstitial fibrosis occurs. Bronchoalveolar lavage (BAL) fluid from these mice had a 3-6 fold increase in surfactant phospholipids. Surfactant proteins A, B, and C showed 2-3 fold increases, while SP-D increased 70 fold. These results indicate that IL-13 is a potent stimulator of surfactant phospholipid and surfactant accumulation in the lung. IL-13 may therefore play a central role in the broad range of chronic pulmonary conditions in which fibrosis, type II cell hypertrophy and surfactant accumulation occur.
This article has been cited by other articles:
|
|
 |
|
  A. V. Andreeva, M. A. Kutuzov, and T. A. Voyno-Yasenetskaya Regulation of surfactant secretion in alveolar type II cells Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L259 - L271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Homer, Z. Zhu, L. Cohn, C. G. Lee, W. I. White, S. Chen, and J. A. Elias Differential expression of chitinases identify subsets of murine airway epithelial cells in allergic inflammation Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L502 - L511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Sorensen, J. v. B. Hjelmborg, K. O. Kyvik, M. Fenger, A. Hoj, C. Bendixen, T. I. A. Sorensen, and U. Holmskov Genetic and environmental influences of surfactant protein D serum levels Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L1010 - L1017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Mora, C. R. Woods, A. Garcia, J. Xu, M. Rojas, S. H. Speck, J. Roman, K. L. Brigham, and A. A. Stecenko Lung infection with {gamma}-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice Am J Physiol Lung Cell Mol Physiol, November 1, 2005; 289(5): L711 - L721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Coraux, B. Nawrocki-Raby, J. Hinnrasky, C. Kileztky, D. Gaillard, C. Dani, and E. Puchelle Embryonic Stem Cells Generate Airway Epithelial Tissue Am. J. Respir. Cell Mol. Biol., February 1, 2005; 32(2): 87 - 92. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Jakubzick, E S Choi, S L Kunkel, H Evanoff, F J Martinez, R K Puri, K R Flaherty, G B Toews, T V Colby, E A Kazerooni, et al. Augmented pulmonary IL-4 and IL-13 receptor subunit expression in idiopathic interstitial pneumonia J. Clin. Pathol., May 1, 2004; 57(5): 477 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Phelps, T. M. Umstead, M. Mejia, G. Carrillo, A. Pardo, and M. Selman Increased Surfactant Protein-A Levels in Patients With Newly Diagnosed Idiopathic Pulmonary Fibrosis Chest, February 1, 2004; 125(2): 617 - 625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhu, G. Enhorning, T. Zheng, Q. Chen, N. Y. Chen, R. Homer, and J. A. Elias Interleukin-13 Induces Surfactant Function Abnormality in the Murine Lung Chest, March 1, 2003; 123(2007): 375S - 376S. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
