AJP - Lung Columbus Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol (January 18, 2002). doi:10.1152/ajplung.00453.2001
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/6/L1245    most recent
00453.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (48)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maus, U. A
Right arrow Articles by Lohmeyer, J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Maus, U. A
Right arrow Articles by Lohmeyer, J.

Articles in PresS, published online ahead of print January 18, 2002
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00453.2001
Submitted on November 26, 2001
Accepted on January 10, 2002

Role of resident alveolar macrophages in leukocyte traffic into the bronchoalveolar space under inflammatory verses non-inflammatory conditions

Ulrich A Maus1*, Audrey M Koay2, Tim Delbeck1, Matthias Mack3, Monika Ermert1, Leander Ermert1, Timothy S Blackwell2, John W Christman2, Detlef Schlondorff3, Werner Seeger1, and Juergen Lohmeyer1

1 Internal Medicine, Justus-Liebig-University, Giessen, Germany
2 Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, and Department of Veterans Affairs, Vanderbilt University School of Medicine, Nashville, TN, USA
3 Medical Policlinic, University of Munich, Munich, Germany

* To whom correspondence should be addressed. E-mail: Ulrich.A.Maus{at}med.uni-giessen.de.

Intratracheal instillation of the monocyte chemoattractant JE/MCP-1 in mice was recently shown to cause increased alveolar monocyte accumulation in the absence of lung inflammation, whereas combined JE/MCP-1/LPS challenge provoked acute lung inflammation with successive waves of early alveolar neutrophil and delayed alveolar monocyte influx. We now evaluated the role of resident alveolar macrophages (rAM) in these leukocyte recruitment events and related phenomena of lung inflammation. Depletion of rAM by pre-treatment of mice with liposome-encapsulated dichloromethylene-diphosphonate (clodronate) did not affect the sole JE/MCP-1 driven alveolar monocyte accumulation, despite the observation that rAM constitutively expressed the JE/MCP-1 receptor, CCR2, as analyzed by flow cytometry and immunohistochemistry. In contrast, depletion of rAM largely suppressed alveolar cytokine release (TNF-{alpha}, MIP-2) as well as alveolar neutrophil and monocyte recruitment profiles following combined JE/MCP-1/LPS treatment. Despite this strongly attenuated alveolar inflammatory response, increased lung vascular permeability with alveolar protein leakage was still observed in the rAM-depleted mice undergoing JE/MCP-1 plus LPS challenge. This leakage response was abrogated by co-depletion of circulating neutrophils or intravenous administration of anti-CD18 mAb. Collectively, rAM are not involved in JE/MCP-1-driven alveolar monocyte recruitment in non-inflamed lungs, but largely contribute to the alveolar cytokine response and the enhanced early neutrophil and delayed monocyte influx under inflammatory conditions (JE/MCP-1 plus LPS deposition). Loss of lung barrier function observed under these conditions is rAM-independent, but involves circulating neutrophils via ß2 integrin engagement.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. S. Farley, L. Wang, and S. Mehta
Septic pulmonary microvascular endothelial cell injury: role of alveolar macrophage NADPH oxidase
Am J Physiol Lung Cell Mol Physiol, March 1, 2009; 296(3): L480 - L488.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Buntinx, B. Hermans, J. Goossens, D. Moechars, R. A. H. J. Gilissen, J. Doyon, S. Boeckx, E. Coesemans, G. Van Lommen, and J. P. Van Wauwe
Pharmacological Profile of JNJ-27141491 [(S)-3-[3,4-Difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl Acid Methyl Ester], as a Noncompetitive and Orally Active Antagonist of the Human Chemokine Receptor CCR2
J. Pharmacol. Exp. Ther., October 1, 2008; 327(1): 1 - 9.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. A. Bem, A. W. Farnand, V. Wong, A. Koski, M. E. Rosenfeld, N. van Rooijen, C. W. Frevert, T. R. Martin, and G. Matute-Bello
Depletion of resident alveolar macrophages does not prevent Fas-mediated lung injury in mice
Am J Physiol Lung Cell Mol Physiol, August 1, 2008; 295(2): L314 - L325.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. Semaeva, O. Tenstad, A. Bletsa, E.-A. B. Gjerde, and H. Wiig
Isolation of rat trachea interstitial fluid and demonstration of local cytokine production in lipopolysaccharide-induced systemic inflammation
J Appl Physiol, March 1, 2008; 104(3): 809 - 820.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. M. Kelly, K. McNagny, D. L. Williams, N. van Rooijen, L. Maxwell, C. Gwozd, C. H. Mody, and P. Kubes
The Lung Responds to Zymosan in a Unique Manner Independent of Toll-Like Receptors, Complement, and Dectin-1
Am. J. Respir. Cell Mol. Biol., February 1, 2008; 38(2): 227 - 238.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
B. Mathew, G. Y. Park, H. Cao, A. C. Azim, X. Wang, R. B. Van Breemen, R. T. Sadikot, and J. W. Christman
Inhibitory {kappa}B Kinase 2 Activates Airway Epithelial Cells to Stimulate Bone Marrow Macrophages
Am. J. Respir. Cell Mol. Biol., May 1, 2007; 36(5): 562 - 572.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
U. A. Maus, M. Backi, C. Winter, M. Srivastava, M. K. Schwarz, T. Ruckle, J. C. Paton, D. Briles, M. Mack, T. Welte, et al.
Importance of Phosphoinositide 3-Kinase {gamma} in the Host Defense against Pneumococcal Infection
Am. J. Respir. Crit. Care Med., May 1, 2007; 175(9): 958 - 966.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K. S. Farley, L. F. Wang, H. M. Razavi, C. Law, M. Rohan, D. G. McCormack, and S. Mehta
Effects of macrophage inducible nitric oxide synthase in murine septic lung injury
Am J Physiol Lung Cell Mol Physiol, June 1, 2006; 290(6): L1164 - L1172.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. M. Meyer, L. D. Dwyer-Nield, G. Hurteau, R. L. Keith, Y. Ouyang, B. M. Freed, L. R. Kisley, M. W. Geraci, J. V. Bonventre, R. A. Nemenoff, et al.
Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice
Am J Physiol Lung Cell Mol Physiol, June 1, 2006; 290(6): L1260 - L1266.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. Vlahos, S. Bozinovski, J. E. Jones, J. Powell, J. Gras, A. Lilja, M. J. Hansen, R. C. Gualano, L. Irving, and G. P. Anderson
Differential protease, innate immunity, and NF-{kappa}B induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice
Am J Physiol Lung Cell Mol Physiol, May 1, 2006; 290(5): L931 - L945.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Knapp, C. W. Wieland, S. Florquin, R. Pantophlet, L. Dijkshoorn, N. Tshimbalanga, S. Akira, and T. van der Poll
Differential Roles of CD14 and Toll-like Receptors 4and 2 in Murine Acinetobacter Pneumonia
Am. J. Respir. Crit. Care Med., January 1, 2006; 173(1): 122 - 129.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. B. Everhart, W. Han, K. S. Parman, V. V. Polosukhin, H. Zeng, R. T. Sadikot, B. Li, F. E. Yull, J. W. Christman, and T. S. Blackwell
Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation
J. Leukoc. Biol., February 1, 2005; 77(2): 173 - 180.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
J. H. Jennings, D. J. Linderman, B. Hu, J. Sonstein, and J. L. Curtis
Monocytes Recruited to the Lungs of Mice during Immune Inflammation Ingest Apoptotic Cells Poorly
Am. J. Respir. Cell Mol. Biol., February 1, 2005; 32(2): 108 - 117.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. Spight, B. Zhao, M. Haas, S. Wert, A. Denenberg, and T. P. Shanley
Immunoregulatory effects of regulated, lung-targeted expression of IL-10 in vivo
Am J Physiol Lung Cell Mol Physiol, February 1, 2005; 288(2): L251 - L265.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
U. A. Maus, S. Wellmann, C. Hampl, W. A. Kuziel, M. Srivastava, M. Mack, M. B. Everhart, T. S. Blackwell, J. W. Christman, D. Schlondorff, et al.
CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels
Am J Physiol Lung Cell Mol Physiol, February 1, 2005; 288(2): L350 - L358.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
P. Puneet, S. Moochhala, and M. Bhatia
Chemokines in acute respiratory distress syndrome
Am J Physiol Lung Cell Mol Physiol, January 1, 2005; 288(1): L3 - L15.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. D. Ye
Leukocyte inflammatory mediators and lung pathophysiology: an update
Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L461 - L462.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. A. Vozzelli, S. N. Mason, M. H. Whorton, and R. L. Auten Jr.
Antimacrophage chemokine treatment prevents neutrophil and macrophage influx in hyperoxia-exposed newborn rat lung
Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L488 - L493.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
U. A. Maus, K. Waelsch, W. A. Kuziel, T. Delbeck, M. Mack, T. S. Blackwell, J. W. Christman, D. Schlondorff, W. Seeger, and J. Lohmeyer
Monocytes Are Potent Facilitators of Alveolar Neutrophil Emigration During Lung Inflammation: Role of the CCL2-CCR2 Axis
J. Immunol., March 15, 2003; 170(6): 3273 - 3278.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2002 by the American Physiological Society.