| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print January 11, 2002
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00463.2001
Submitted on December 4, 2001
Accepted on January 10, 2002
1 Molecular Genetics, University of Illinois at Chicago, Chicago, IL, USA
2 Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA, USA
3 Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, OH, USA
* To whom correspondence should be addressed. E-mail: robcosta{at}uic.edu.
The Forkhead Box (Fox) family of transcription factors plays important roles in regulating expression of genes involved in cellular proliferation and differentiation. In a previous study, we showed that newborn Foxf1 +/- mice with diminished Foxf1 levels exhibited abnormal formation of pulmonary alveoli and capillaries and died postnatally. Interestingly, surviving newborn Foxf1 +/- mice exhibited increased pulmonary Foxf1 levels and normal adult lung morphology, suggesting that wild type Foxf1 levels are required for lung development and function. The present study was conducted to determine whether adult Foxf1 +/- mice were able to undergo lung repair similar to that observed in wild type mice. We demonstrated that adult Foxf1 +/- mice died from severe lung hemorrhage following Butylated Hydroxytoluene (BHT) lung injury and that this phenotype was associated with a 10-fold decrease in pulmonary Foxf1 expression and increased alveolar endothelial cell apoptosis that disrupted capillary integrity. Furthermore, BHT induced lung hemorrhage of adult Foxf1 +/- mice was associated with a drastic reduction in expression of the Flk-1, Bmp-4, Surfactant Protein B (SP-B), Pecam-1 and Vascular Endothelial (VE) cadherin genes, whereas the expression of these genes was either transiently diminished or increased in wild type lungs following BHT injury. Because these proteins are critical for lung morphogenesis and endothelial homeostasis, their decreased mRNA levels are likely contributing to BHT induced lung hemorrhage in Foxf1 +/- mice. Collectively, our data suggest that sustained expression of Foxf1 is essential for normal lung repair and endothelial cell survival in response to pulmonary cell injury.
This article has been cited by other articles:
|
|
 |
|
  T. V. Kalin, L. Meliton, A. Y. Meliton, X. Zhu, J. A. Whitsett, and V. V. Kalinichenko Pulmonary Mastocytosis and Enhanced Lung Inflammation in Mice Heterozygous Null for the Foxf1 Gene Am. J. Respir. Cell Mol. Biol., October 1, 2008; 39(4): 390 - 399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. N. Papanicolaou, Y. Izumiya, and K. Walsh Forkhead Transcription Factors and Cardiovascular Biology Circ. Res., January 4, 2008; 102(1): 16 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Malin, I.-M. Kim, E. Boetticher, T. V. Kalin, S. Ramakrishna, L. Meliton, V. Ustiyan, X. Zhu, and V. V. Kalinichenko Forkhead Box F1 Is Essential for Migration of Mesenchymal Cells and Directly Induces Integrin-Beta3 Expression Mol. Cell. Biol., April 1, 2007; 27(7): 2486 - 2498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Maeda, V. Dave, and J. A. Whitsett Transcriptional Control of Lung Morphogenesis Physiol Rev, January 1, 2007; 87(1): 219 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Spira, J. Beane, V. Pinto-Plata, A. Kadar, G. Liu, V. Shah, B. Celli, and J. S. Brody Gene Expression Profiling of Human Lung Tissue from Smokers with Severe Emphysema Am. J. Respir. Cell Mol. Biol., December 1, 2004; 31(6): 601 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. H. Lim, A. Aggarwal, T. Agasthian, P.-S. Wong, C. Tan, E. Sim, L. Tan, P.-S. Goh, S.-C. Wang, K.-L. Khoo, et al. Feasibility of Using Low-Volume Tissue Samples for Gene Expression Profiling of Advanced Non-Small Cell Lung Cancers Clin. Cancer Res., December 1, 2003; 9(16): 5980 - 5987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Favre, M. Mancuso, K. Maas, J. W. McLean, P. Baluk, and D. M. McDonald Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H1917 - H1938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. V. Kalinichenko, G. A. Gusarova, Y. Tan, I-C. Wang, M. L. Major, X. Wang, H. M. Yoder, and R. H. Costal Ubiquitous Expression of the Forkhead Box M1B Transgene Accelerates Proliferation of Distinct Pulmonary Cell Types following Lung Injury J. Biol. Chem., September 26, 2003; 278(39): 37888 - 37894. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
