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Articles in PresS, published online ahead of print June 14, 2002
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00488.2001
Submitted on December 20, 2001
Accepted on June 7, 2002
1 Department of Physiology, University of South Alabama, Mobile, AL, USA
* To whom correspondence should be addressed. E-mail: jparker{at}usouthal.edu.
The response of segmental filtration coefficients (Kf) to high peak inflation pressure (PIP)injury was determined in isolated perfuse rat lungs. Total (Kf,t), arterial (Kf,a), and venous (Kf,v)filtration coefficients were measured under baseline conditions and after ventilation with 40-45 cmH2O PIP. Kf,a and Kf,v were measured under zone I conditions by increasing airway pressure to 25-27 cmH2O. The microvascular segment Kf (Kf,mv) was then calculated by: Kf,mv = Kf,t - Kf,a - Kf,v. The baseline Kf,t was 0.090±0.022 ml/min/cmH2O/100g and segmentally distributed 18% arterial, 41% venous and 41% microvascular. After high PIP injury, total Kf increased by 680%, while arterial, venous and microvascular Kf increased by 398%, 589% and 975%, respectively. Pretreatment with 50 µM GdCl3 prevented the high PIP-induced increase in Kf in all vascular segments. These data imply a lower hydraulic conductance for microvascular endothelium due to its large surface area and a gadolinium sensitive high PIP injury to both alveolar and extra-alveolar vessels segments.
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