AJP - Lung Columbus Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Lung Cell Mol Physiol (February 1, 2002). doi:10.1152/ajplung.00490.2001
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/6/L1272    most recent
00490.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (27)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leuwerke, S. M
Right arrow Articles by Laubach, V. E
Right arrow Search for Related Content
PubMed
Right arrow Articles by Leuwerke, S. M
Right arrow Articles by Laubach, V. E

Articles in PresS, published online ahead of print February 1, 2002
Am J Physiol Lung Cell Mol Physiol, 10.1152/ajplung.00490.2001
Submitted on December 21, 2001
Accepted on January 30, 2002

Inhibition of compensatory lung growth in endothelial nitric oxide synthase-deficient mice

Shari M Leuwerke1, Aditya K Kaza1, Curtis G Tribble1, Irving L Kron1, and Victor E Laubach1*

1 Surgery, University of Virginia Health System, Charlottesville, VA, USA

* To whom correspondence should be addressed. E-mail: vel8n{at}virginia.edu.

Pneumonectomy results in rapid compensatory growth of the remaining lung and also leads to increased flow and shear stress which are known to stimulate endothelial nitric oxide synthase (eNOS). NO is an essential mediator of vascular endothelial growth factor-induced angiogenesis, which should necessarily occur during compensatory lung growth. Thus, our hypothesis is that eNOS is critical for compensatory lung growth. To test this, left pneumonectomy was performed in eNOS-deficient mice (eNOS-/-), and compensatory growth of the right lung was characterized throughout 14 days post-pneumonectomy and compared to wild-type pneumonectomy and sham controls. Compensatory lung growth was severely impaired in eNOS-/- mice as demonstrated by significant reductions in lung weight index, lung volume index, and volume of respiratory region. Also, pneumonectomy-induced increases in alveolar surface density and cell proliferation were prevented in eNOS-/- mice, indicating that eNOS plays a role in alveolar hyperplasia. Compensatory lung growth was also impaired in wild-type mice treated with the NOS inhibitor, L-NAME. Taken together, these results indicate that eNOS is critical for compensatory lung growth.




This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
V. Bhandari, R. Choo-Wing, C. G. Lee, K. Yusuf, J. H. Nedrelow, N. Ambalavanan, H. Malkus, R. J. Homer, and J. A. Elias
Developmental Regulation of NO-Mediated VEGF-Induced Effects in the Lung
Am. J. Respir. Cell Mol. Biol., October 1, 2008; 39(4): 420 - 430.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. D. Nolen-Walston, C. F. Kim, M. R. Mazan, E. P. Ingenito, A. M. Gruntman, L. Tsai, R. Boston, A. E. Woolfenden, T. Jacks, and A. M. Hoffman
Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration
Am J Physiol Lung Cell Mol Physiol, June 1, 2008; 294(6): L1158 - L1165.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
L. G. Fernandez, C. K. Mehta, I. L. Kron, and V. E. Laubach
Reinitiation of compensatory lung growth after subsequent lung resection.
J. Thorac. Cardiovasc. Surg., November 1, 2007; 134(5): 1300 - 1305.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z. Liu, Y. Jiang, H. Hao, K. Gupta, J. Xu, L. Chu, E. McFalls, J. Zweier, C. Verfaillie, and R. J. Bache
Endothelial nitric oxide synthase is dynamically expressed during bone marrow stem cell differentiation into endothelial cells
Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1760 - H1765.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Vyas-Read, P. W. Shaul, I. S. Yuhanna, and B. C. Willis
Nitric oxide attenuates epithelial-mesenchymal transition in alveolar epithelial cells
Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L212 - L221.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
L. G. Fernandez, T. D. Le Cras, M. Ruiz, D. K. Glover, I. L. Kron, and V. E. Laubach
Differential vascular growth in postpneumonectomy compensatory lung growth
J. Thorac. Cardiovasc. Surg., February 1, 2007; 133(2): 309 - 316.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
V. Balasubramaniam, A. M. Maxey, D. B. Morgan, N. E. Markham, and S. H. Abman
Inhaled NO restores lung structure in eNOS-deficient mice recovering from neonatal hypoxia
Am J Physiol Lung Cell Mol Physiol, July 1, 2006; 291(1): L119 - L127.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. S. Maxey, L. G. Fernandez, T. B. Reece, W. B. Keeling, I. L. Kron, and V. E. Laubach
Endothelial Nitric Oxide Synthase is Essential for Postpneumonectomy Compensatory Vasodilation
Ann. Thorac. Surg., April 1, 2006; 81(4): 1234 - 1238.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. D. Bland, K. H. Albertine, D. P. Carlton, and A. J. MacRitchie
Inhaled Nitric Oxide Effects on Lung Structure and Function in Chronically Ventilated Preterm Lambs
Am. J. Respir. Crit. Care Med., October 1, 2005; 172(7): 899 - 906.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. D. Le Cras, L. G. Fernandez, P. A. Pastura, and V. E. Laubach
Vascular growth and remodeling in compensatory lung growth following right lobectomy
J Appl Physiol, March 1, 2005; 98(3): 1140 - 1148.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Voswinckel, V. Motejl, A. Fehrenbach, M. Wegmann, T. Mehling, H. Fehrenbach, and W. Seeger
Characterisation of post-pneumonectomy lung growth in adult mice
Eur. Respir. J., October 1, 2004; 24(4): 524 - 532.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Mechanisms and Limits of Induced Postnatal Lung Growth
Am. J. Respir. Crit. Care Med., August 1, 2004; 170(3): 319 - 343.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J.-R. Tang, N. E. Markham, Y.-J. Lin, I. F. McMurtry, A. Maxey, J. P. Kinsella, and S. H. Abman
Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor
Am J Physiol Lung Cell Mol Physiol, August 1, 2004; 287(2): L344 - L351.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Hjoberg, S. Shore, L. Kobzik, S. Okinaga, A. Hallock, J. Vallone, V. Subramaniam, G. T. De Sanctis, J. A. Elias, J. M. Drazen, et al.
Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness
J Appl Physiol, July 1, 2004; 97(1): 249 - 259.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. N.N. Han, S. Babaei, M. Robb, T. Lee, R. Ridsdale, C. Ackerley, M. Post, and D. J. Stewart
Defective Lung Vascular Development and Fatal Respiratory Distress in Endothelial NO Synthase-Deficient Mice: A Model of Alveolar Capillary Dysplasia?
Circ. Res., April 30, 2004; 94(8): 1115 - 1123.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. Voswinckel, T. Ziegelhoeffer, M. Heil, S. Kostin, G. Breier, T. Mehling, R. Haberberger, M. Clauss, A. Gaumann, W. Schaper, et al.
Circulating Vascular Progenitor Cells Do Not Contribute to Compensatory Lung Growth
Circ. Res., August 22, 2003; 93(4): 372 - 379.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
V. Balasubramaniam, J.-R. Tang, A. Maxey, C. G. Plopper, and S. H. Abman
Mild hypoxia impairs alveolarization in the endothelial nitric oxide synthase-deficient mouse
Am J Physiol Lung Cell Mol Physiol, June 1, 2003; 284(6): L964 - L971.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2002 by the American Physiological Society.