| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States
* To whom correspondence should be addressed. E-mail: irshad.chaudry{at}ccc.uab.edu.
Previous studies have shown that females in the proestrus stage of their reproductive cycle maintain organ functions following trauma-hemorrhage. However, it remains unknown whether the female reproductive cycle is an important variable in the regulation of lung injury following trauma-hemorrhage and if so, whether the effect is mediated via up regulation of hemeoxygenase (HO)-1. To examine this, female Sprague-Dawley rats during the diestrus, proestrus, estrus, and metestrus phase of the reproductive cycle or 14 days after ovariectomy, underwent soft tissue trauma and then hemorrhage (mean blood pressure 40 mmHg for 90 min followed by fluid resuscitation). At 2 hrs after trauma-hemorrhage or sham operation, lung myeloperoxidase (MPO) activity, intercellular adhesion molecule (ICAM)-1, cytokine-induced neutrophil chemoattractant (CINC)-1, CINC-3 and HO-1 protein levels were measured. Plasma 17
-estradiol concentration was also determined. The results indicated that trauma-hemorrhage increased lung MPO activity, ICAM-1, CINC-1, and CINC-3 levels in ovariectomized-females. These parameters were found to be similar to shams in the proestrus female rats subjected to trauma-hemorrhage. Lung HO-1 protein level in proestrus females was increased significantly compared to female rats subjected to trauma-hemorrhage during diestrus, estrus, metestrus phases of reproductive cycle and ovariectomized rats. Furthermore, plasma 17-estradiol level was highest in proestrus females. Administration of the HO inhibitor, chromium-mesoporphyrin (CrMP), prevented the proestrus female-induced attenuation of shock-induced lung damage. Thus, these finding suggest that female reproductive cycle is an important variable in the regulation of lung injury following trauma-hemorrhage and that the protective effect in proestrus females are likely mediated via upregulation of HO-1.
This article has been cited by other articles:
|
|
 |
|
  S. Akhtar, X. Li, I. H. Chaudry, and M. A. Choudhry Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O2- production and intestinal edema following alcohol intoxication and burn injury Am J Physiol Gastrointest Liver Physiol, August 1, 2009; 297(2): G340 - G347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Yang, S. Hu, J. Chen, M. A. Choudhry, L. W. Rue III, K. I. Bland, and I. H. Chaudry Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responses J. Leukoc. Biol., June 1, 2009; 85(6): 1015 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.-C. Liu, Y.-J. Day, C.-H. Liao, J.-T. Liou, C.-C. Mao, and H.-P. Yu Hemeoxygenase-1 Upregulation Is Critical for Sirtinol-Mediated Attenuation of Lung Injury After Trauma-Hemorrhage in a Rodent Model Anesth. Analg., June 1, 2009; 108(6): 1855 - 1861. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Masini, A. Vannacci, P. Failli, R. Mastroianni, L. Giannini, M. C. Vinci, C. Uliva, R. Motterlini, and P. F. Mannaioni A carbon monoxide-releasing molecule (CORM-3) abrogates polymorphonuclear granulocyte-induced activation of endothelial cells and mast cells FASEB J, September 1, 2008; 22(9): 3380 - 3388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Raju and I. H. Chaudry Sex Steroids/Receptor Antagonist: Their Use as Adjuncts After Trauma-Hemorrhage for Improving Immune/Cardiovascular Responses and for Decreasing Mortality from Subsequent Sepsis Anesth. Analg., July 1, 2008; 107(1): 159 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Choudhry and I. H. Chaudry 17{beta}-Estradiol: a novel hormone for improving immune and cardiovascular responses following trauma-hemorrhage J. Leukoc. Biol., March 1, 2008; 83(3): 518 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Li, E. J. Kovacs, M. G. Schwacha, I. H. Chaudry, and M. A. Choudhry Acute alcohol intoxication increases interleukin-18-mediated neutrophil infiltration and lung inflammation following burn injury in rats Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1193 - L1201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-C. Hsieh, M. Frink, C.-H. Hsieh, M. A. Choudhry, M. G. Schwacha, K. I. Bland, and I. H. Chaudry Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1227 - L1232. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
