| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 and 2 Division of Pulmonary and Care Medicine, Yale University, New Haven, Connecticut 06520
The discovery of the gaseous molecule nitric oxide in 1987 unraveled investigations on its functional role in the pathogenesis of a wide spectrum of biological and pathological processes. At that time, the novel concept that an endogenous production of a gaseous substance such as nitric oxide can impart such diverse and potent cellular effects proved to be very fruitful in enhancing our understanding of many disease processes including lung disorders. Interestingly, we have known for a longer period of time that there exists another gaseous molecule that is also generated endogenously; the heme oxygenase (HO) enzyme system generates the majority if not all of the endogenously produced carbon monoxide. This enzyme system also liberates two other by-products, bilirubin and ferritin, each possessing important biological functions and helping to define the uniqueness of the HO enzyme system. In recent years, interest in HO has emerged in numerous disciplines including the central nervous system, cardiovascular physiology, renal and hepatic systems, and transplantation. We review the functional role of HO in lung biology and its real potential application to lung diseases.
carbon monoxide; oxidative stress; acute lung injury; stress response genes
This article has been cited by other articles:
|
|
 |
|
  Y.-M. Sue, C.-F. Cheng, C.-C. Chang, Y. Chou, C.-H. Chen, and S.-H. Juan Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethylpyrazine against gentamicin-induced apoptosis in murine renal tubular cells Nephrol. Dial. Transplant., October 8, 2008; (2008) gfn545v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ueda, T. Ueyama, K.-i. Yoshida, H. Kimura, T. Ito, Y. Shimizu, M. Oka, Y. Tsuruo, and M. Ichinose Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions Am J Physiol Gastrointest Liver Physiol, September 1, 2008; 295(3): G460 - G469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Dassen, R. Kamps, C. Punyadeera, F. Dijcks, A. de Goeij, A. Ederveen, G. Dunselman, and P. Groothuis Haemoglobin expression in human endometrium Hum. Reprod., March 1, 2008; 23(3): 635 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Hsieh, S.-F. Jeng, M.-W. Hsieh, Y.-C. Chen, C.-S. Rau, T.-H. Lu, and S.-S. Chen Statin-Induced Heme Oxygenase-1 Increases NF-{kappa}B Activation and Oxygen Radical Production in Cultured Neuronal Cells Exposed to Lipopolysaccharide Toxicol. Sci., March 1, 2008; 102(1): 150 - 159. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wang, J.-Y. S. Lee, J. H. Kwak, Y. He, S. I. Kim, and M. E. Choi Protective effects of low-dose carbon monoxide against renal fibrosis induced by unilateral ureteral obstruction Am J Physiol Renal Physiol, March 1, 2008; 294(3): F508 - F517. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Frank, C. Kuhn, B. Brors, C. Hanselmann, M. Ludde, H. A. Katus, and N. Frey Gene Expression Pattern in Biomechanically Stretched Cardiomyocytes: Evidence for a Stretch-Specific Gene Program Hypertension, February 1, 2008; 51(2): 309 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Hsieh, C.-S. Rau, M.-W. Hsieh, Y.-C. Chen, S.-F. Jeng, T.-H. Lu, and S.-S. Chen Simvastatin-Induced Heme Oxygenase-1 Increases Apoptosis of Neuro 2A Cells in Response to Glucose Deprivation Toxicol. Sci., January 1, 2008; 101(1): 112 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Bathoorn, D-J. Slebos, D. S. Postma, G. H. Koeter, A. J. M. van Oosterhout, M. van der Toorn, H. M. Boezen, and H. A. M. Kerstjens Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study Eur. Respir. J., December 1, 2007; 30(6): 1131 - 1137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Chabannes, M. Hill, E. Merieau, J. Rossignol, R. Brion, J. P. Soulillou, I. Anegon, and M. C. Cuturi A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells Blood, November 15, 2007; 110(10): 3691 - 3694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Grion, E M Repetto, Y Pomeraniec, C M. Calejman, F Astort, R Sanchez, O P Pignataro, P Arias, and C B Cymeryng Induction of nitric oxide synthase and heme oxygenase activities by endotoxin in the rat adrenal cortex: involvement of both signaling systems in the modulation of ACTH-dependent steroid production J. Endocrinol., July 1, 2007; 194(1): 11 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-M. Hu, H.-H. Lin, M.-T. Chiang, P.-F. Chang, and L.-Y. Chau Systemic Expression of Heme Oxygenase-1 Ameliorates Type 1 Diabetes in NOD Mice Diabetes, May 1, 2007; 56(5): 1240 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tiroch, W. Koch, N. von Beckerath, A. Kastrati, and A. Schomig Heme oxygenase-1 gene promoter polymorphism and restenosis following coronary stenting Eur. Heart J., April 2, 2007; 28(8): 968 - 973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Basuroy, S. Bhattacharya, D. Tcheranova, Y. Qu, R. F. Regan, C. W. Leffler, and H. Parfenova HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-{alpha} in cerebral vascular endothelial cells Am J Physiol Cell Physiol, November 1, 2006; 291(5): C897 - C908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Schaer, G. Schoedon, A. Imhof, M. O. Kurrer, and D. J. Schaer Constitutive Endocytosis of CD163 Mediates Hemoglobin-Heme Uptake and Determines the Noninflammatory and Protective Transcriptional Response of Macrophages to Hemoglobin Circ. Res., October 27, 2006; 99(9): 943 - 950. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Zuckerbraun, B. Y. Chin, B. Wegiel, T. R. Billiar, E. Czsimadia, J. Rao, L. Shimoda, E. Ifedigbo, S. Kanno, and L. E. Otterbein Carbon monoxide reverses established pulmonary hypertension J. Exp. Med., September 4, 2006; 203(9): 2109 - 2119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Pryor, K. N. Houk, C. S. Foote, J. M. Fukuto, L. J. Ignarro, G. L. Squadrito, and K. J. A. Davies Free radical biology and medicine: it's a gas, man! Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R491 - R511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Erdmann, N. Grosser, K. Schipporeit, and H. Schroder The ACE Inhibitory Dipeptide Met-Tyr Diminishes Free Radical Formation in Human Endothelial Cells via Induction of Heme Oxygenase-1 and Ferritin J. Nutr., August 1, 2006; 136(8): 2148 - 2152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Z. Khaldi, H. Elouil, Y. Guiot, J. C. Henquin, and J. C. Jonas Antioxidants N-acetyl-L-cysteine and manganese(III)tetrakis (4-benzoic acid)porphyrin do not prevent beta-cell dysfunction in rat islets cultured in high glucose for 1 wk Am J Physiol Endocrinol Metab, July 1, 2006; 291(1): E137 - E146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Parfenova, S. Basuroy, S. Bhattacharya, D. Tcheranova, Y. Qu, R. F. Regan, and C. W. Leffler Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of HO-1 and HO-2 to cytoprotection Am J Physiol Cell Physiol, May 1, 2006; 290(5): C1399 - C1410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Overhaus, B. A. Moore, J. E. Barbato, F. F. Behrendt, J. G. Doering, and A. J. Bauer Biliverdin protects against polymicrobial sepsis by modulating inflammatory mediators Am J Physiol Gastrointest Liver Physiol, April 1, 2006; 290(4): G695 - G703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Kirkby and C. A. Adin Products of heme oxygenase and their potential therapeutic applications Am J Physiol Renal Physiol, March 1, 2006; 290(3): F563 - F571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Pachori, L. G. Melo, L. Zhang, S. D. Solomon, and V. J. Dzau Chronic Recurrent Myocardial Ischemic Injury Is Significantly Attenuated by Pre-Emptive Adeno-Associated Virus Heme Oxygenase-1 Gene Delivery J. Am. Coll. Cardiol., February 7, 2006; 47(3): 635 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Neto, A. Nakao, H. Toyokawa, M. A. Nalesnik, A. J. Romanosky, K. Kimizuka, T. Kaizu, N. Hashimoto, O. Azhipa, D. B. Stolz, et al. Low-dose carbon monoxide inhalation prevents development of chronic allograft nephropathy Am J Physiol Renal Physiol, February 1, 2006; 290(2): F324 - F334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wu and R. Wang Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications Pharmacol. Rev., December 1, 2005; 57(4): 585 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shiraishi and K. Naito Increased expression of Leydig cell haem oxygenase-1 preserves spermatogenesis in varicocele Hum. Reprod., September 1, 2005; 20(9): 2608 - 2613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Zuckerbraun, L. E. Otterbein, P. Boyle, R. Jaffe, J. Upperman, R. Zamora, and H. R. Ford Carbon monoxide protects against the development of experimental necrotizing enterocolitis Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G607 - G613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chauveau, S. Remy, P. J. Royer, M. Hill, S. Tanguy-Royer, F.-X. Hubert, L. Tesson, R. Brion, G. Beriou, M. Gregoire, et al. Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression Blood, September 1, 2005; 106(5): 1694 - 1702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Dawn and R. Bolli HO-1 induction by HIF-1: a new mechanism for delayed cardioprotection? Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H522 - H524. [Full Text] [PDF]
|
|
|
|
|
|
A. Uc, R. F. Husted, R. L. Giriyappa, B. E. Britigan, and J. B. Stokes Hemin induces active chloride secretion in Caco-2 cells Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G202 - G208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nakao, N. Murase, C. Ho, H. Toyokawa, T. R. Billiar, and S. Kanno Biliverdin Administration Prevents the Formation of Intimal Hyperplasia Induced by Vascular Injury Circulation, July 26, 2005; 112(4): 587 - 591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ghosh, M. R. Wilson, S. Choudhury, H. Yamamoto, M. E. Goddard, B. Falusi, N. Marczin, and M. Takata Effects of inhaled carbon monoxide on acute lung injury in mice Am J Physiol Lung Cell Mol Physiol, June 1, 2005; 288(6): L1003 - L1009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Filippo, R. Marfella, S. Cuzzocrea, E. Piegari, P. Petronella, D. Giugliano, F. Rossi, and M. D'Amico Hyperglycemia in Streptozotocin-Induced Diabetic Rat Increases Infarct Size Associated With Low Levels of Myocardial HO-1 During Ischemia/Reperfusion Diabetes, March 1, 2005; 54(3): 803 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Omura, H. Suzuki, M. Toyofuku, R. Ozono, N. Kohno, and K. Igarashi Effects of genetic ablation of bach1 upon smooth muscle cell proliferation and atherosclerosis after cuff injury Genes Cells, March 1, 2005; 10(3): 277 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Chung, Y.-H. Chen, and M. A. Perrella Role of Ets-2 in the Regulation of Heme Oxygenase-1 by Endotoxin J. Biol. Chem., February 11, 2005; 280(6): 4578 - 4584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C M Harrison and C C Andersen Exhaled breath measures of inflammation: are they useful in neonatal chronic lung disease? Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2005; 90(1): F6 - F10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. G. Abraham, R. Rezzani, L. Rodella, A. Kruger, D. Taller, G. Li Volti, A. I. Goodman, and A. Kappas Overexpression of human heme oxygenase-1 attenuates endothelial cell sloughing in experimental diabetes Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2468 - H2477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tongers, B. Fiedler, D. Konig, T. Kempf, G. Klein, J. Heineke, T. Kraft, S. Gambaryan, S. M Lohmann, H. Drexler, et al. Heme oxygenase-1 inhibition of MAP kinases, calcineurin/NFAT signaling, and hypertrophy in cardiac myocytes Cardiovasc Res, August 15, 2004; 63(3): 545 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hayashi, T. Takahashi, H. Morimatsu, H. Fujii, N. Taga, S. Mizobuchi, M. Matsumi, H. Katayama, M. Yokoyama, M. Taniguchi, et al. Increased Carbon Monoxide Concentration in Exhaled Air After Surgery and Anesthesia Anesth. Analg., August 1, 2004; 99(2): 444 - 448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Almolki, C. Taille, G. F. Martin, P. J. Jose, C. Zedda, M. Conti, J. Megret, D. Henin, M. Aubier, and J. Boczkowski Heme oxygenase attenuates allergen-induced airway inflammation and hyperreactivity in guinea pigs Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L26 - L34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Porubsky, H. Schmid, M. Bonrouhi, M. Kretzler, E. Malle, P. J. Nelson, and H.-J. Grone Influence of Native and Hypochlorite-Modified Low-Density Lipoprotein on Gene Expression in Human Proximal Tubular Epithelium Am. J. Pathol., June 1, 2004; 164(6): 2175 - 2187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. L. Tang, Y. Tang, Y. C. Zhang, K. Qian, L. Shen, and M. I. Phillips Protection From Ischemic Heart Injury by a Vigilant Heme Oxygenase-1 Plasmid System Hypertension, April 1, 2004; 43(4): 746 - 751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Atzori, F Chua, S E Dunsmore, D Willis, M Barbarisi, R J McAnulty, and G J Laurent Attenuation of bleomycin induced pulmonary fibrosis in mice using the heme oxygenase inhibitor Zn-deuteroporphyrin IX-2,4-bisethylene glycol Thorax, March 1, 2004; 59(3): 217 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Sikorski, T. Hock, N. Hill-Kapturczak, and A. Agarwal The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury Am J Physiol Renal Physiol, March 1, 2004; 286(3): F425 - F441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Chen, L.-Y. Chau, M.-W. Lin, L.-C. Chen, M.-H. Yo, J.-W. Chen, and S.-J. Lin Heme oxygenase-1 gene promotor microsatellite polymorphism is associated with angiographic restenosis after coronary stenting Eur. Heart J., January 1, 2004; 25(1): 39 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Zhang, J. I. Kaide, L. Yang, H. Jiang, S. Quan, R. Kemp, W. Gong, M. Balazy, N. G. Abraham, and A. Nasjletti CO modulates pulmonary vascular response to acute hypoxia: relation to endothelin Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H137 - H144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Suzuki, M. Muramatsu, T. Kojima, and W. Taki Intracranial Heme Metabolism and Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage Stroke, December 1, 2003; 34(12): 2796 - 2800. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Abeyama, K.-i. Kawahara, S. Iino, T. Hamada, S.-i. Arimura, K. Matsushita, T. Nakajima, and I. Maruyama Antibiotic cyclic AMP signaling by "primed" leukocytes confers anti-inflammatory cytoprotection J. Leukoc. Biol., November 1, 2003; 74(5): 908 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Risom, M. Dybdahl, J. Bornholdt, U. Vogel, H. Wallin, P. Moller, and S. Loft Oxidative DNA damage and defence gene expression in the mouse lung after short-term exposure to diesel exhaust particles by inhalation Carcinogenesis, November 1, 2003; 24(11): 1847 - 1852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Nakao, B A Moore, N Murase, F Liu, B S Zuckerbraun, F H Bach, A M K Choi, M A Nalesnik, L E Otterbein, and A J Bauer Immunomodulatory effects of inhaled carbon monoxide on rat syngeneic small bowel graft motility Gut, September 1, 2003; 52(9): 1278 - 1285. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. Kaminski, J. A. Belperio, P. B. Bitterman, L. Chen, S. W. Chensue, A. M.K. Choi, S. Dacic, J. H. Dauber, R. M. du Bois, J. J. Enghild, et al. Idiopathic Pulmonary Fibrosis Am. J. Respir. Cell Mol. Biol., September 1, 2003; 29(3): S1 - 105. [Full Text] [PDF]
|
|
|
|
|
|
F. A. D. T. G. Wagener, H.-D. Volk, D. Willis, N. G. Abraham, M. P. Soares, G. J. Adema, and C. G. Figdor Different Faces of the Heme-Heme Oxygenase System in Inflammation Pharmacol. Rev., September 1, 2003; 55(3): 551 - 571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hirai, H. Kubo, M. Yamaya, K. Nakayama, M. Numasaki, S. Kobayashi, S. Suzuki, S. Shibahara, and H. Sasaki Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines Blood, September 1, 2003; 102(5): 1619 - 1621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Song, M. Kubo, D. Morse, Z. Zhou, X. Zhang, J. H. Dauber, J. Fabisiak, S. M. Alber, S. C. Watkins, B. S. Zuckerbraun, et al. Carbon Monoxide Induces Cytoprotection in Rat Orthotopic Lung Transplantation via Anti-Inflammatory and Anti-Apoptotic Effects Am. J. Pathol., July 1, 2003; 163(1): 231 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-H. Chen, S.-F. Yet, and M. A. Perrella Role of Heme Oxygenase-1 in the Regulation of Blood Pressure and Cardiac Function Experimental Biology and Medicine, May 1, 2003; 228(5): 447 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Colombrita, V. Calabrese, A. M. G. Stella, F. Mattei, D. L. Alkon, and G. Scapagnini Regional Rat Brain Distribution of Heme Oxygenase-1 and Manganese Superoxide Dismutase mRNA: Relevance of Redox Homeostasis in the Aging Processes Experimental Biology and Medicine, May 1, 2003; 228(5): 517 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Guillot, S. Menoret, C. Guillonneau, C. Braudeau, M. G. Castro, P. Lowenstein, and I. Anegon Active suppression of allogeneic proliferative responses by dendritic cells after induction of long-term allograft survival by CTLA4Ig Blood, April 15, 2003; 101(8): 3325 - 3333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. de Perrot, M. Liu, T. K. Waddell, and S. Keshavjee Ischemia-Reperfusion-induced Lung Injury Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 490 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Genter, D. M. Burman, S. Vijayakumar, C. L. Ebert, and B. J. Aronow Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa Physiol Genomics, December 26, 2002; 12(1): 35 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
|
